RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
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P1343
A molecular mechanism for eflornithine resistance in African trypanosomesUntargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma bruceiMathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identificationPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesGenetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylaseA Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.Spermidine synthase is required for virulence of Leishmania donovani.Arginine and Lysine Transporters Are Essential for Trypanosoma bruceiThe silicon trypanosome: a test case of iterative model extension in systems biology.Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozymeTrypanocidal drugs: mechanisms, resistance and new targets.Metabolomic systems biology of trypanosomes.The silicon trypanosome.State of the art in African trypanosome drug discovery.Development of novel drugs for human African trypanosomiasis.Profiling the aminopropyltransferases in plants: their structure, expression and manipulation.Drug resistance in human African trypanosomiasis.Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases.Pharmacological Metabolomics in Trypanosomes
P2860
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P2860
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 20 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@en
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@nl
type
label
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@en
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@nl
prefLabel
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@en
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@nl
P2093
P2860
P921
P356
P1433
P1476
RNA interference-mediated sile ...... ion of polyamine biosynthesis.
@en
P2093
Diane E McCloskey
Margaret A Phillips
Yanjing Xiao
P2860
P304
P356
10.1128/EC.00047-09
P577
2009-03-20T00:00:00Z