Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
about
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulationNeuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathwayAph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substratesIntramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neuronsGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaThe canonical Notch signaling pathway: unfolding the activation mechanism.Postmortem brain: an underutilized substrate for studying severe mental illnessGenetic models of sensorimotor gating: relevance to neuropsychiatric disorders.Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspectsModeling an anti-amyloid combination therapy for Alzheimer's disease.Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranesPharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP.Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findingsPresenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesMultiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients.Presenilin: RIP and beyond.gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.Signature amyloid β profiles are produced by different γ-secretase complexes.The audacity of proteomics: a chance to overcome current challenges in schizophrenia research.The structure and function of Alzheimer's gamma secretase enzyme complex.Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches.Genetics and smoking.Proteolytic cleavage of Notch: "HIT and RUN".Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseasesNeuregulin 3 and its roles in schizophrenia risk and presentation.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling.In silico analysis of neuregulin 1 evolution in vertebrates.Changes in Neuropsychiatric Inventory Associated with Semagacestat Treatment of Alzheimer's Disease.Calcyon stimulates neuregulin 1 maturation and signaling.Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model.Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice.
P2860
Q24610713-3E09BB65-D3FB-43AE-9E7C-4EE03E61AD93Q28285114-2656BF17-79C1-434C-9FBA-CBBB2B24E84DQ28570929-ADEE45CE-6D81-4725-A0A3-59E2196B5FB6Q28589393-BF7E32FA-5A75-421E-97E9-B6537878EAA5Q28595013-0EF3E3F7-1D37-46E1-92B9-F0CF7E89248BQ28600984-DF6178E9-7EDF-444F-BFC5-5AE0B9011B3AQ29547725-52B1C370-26C1-497C-8908-1A80EE6B12FCQ30422050-C9CACF38-A17F-4280-BA8C-E00813196740Q30459497-99EDFADF-76FE-4F23-9480-2EBA2B597E16Q30476813-A6B41505-CB97-4E19-B242-F6E69CED3417Q30482113-CD85916D-8B7F-4B38-8516-954D3D65B725Q30762130-7EF1534B-4B8C-47C8-9676-1419C8AC7E77Q33545253-43D6C029-D1D2-407F-8BBA-43416F59D698Q33754831-A738FB3E-0E0E-4F65-8AC5-BE978B4AE5ABQ33814276-1A21F078-65BA-4DC3-876B-398DA54FAA40Q33862796-ADF01C50-6F9E-4312-8B05-35DDA313C362Q34110227-197939EF-9CDE-46AA-8784-92ADDEEF857AQ34270737-0E3402E3-A18F-4826-B3A0-18BBAA553464Q35658184-E007BED5-314B-447B-8681-3F2CAEBC6A67Q35668723-04F757E0-C1A3-4AB3-B8B4-ACCFB4F67F6DQ36419261-C774F3BE-4805-4B93-8E15-F2BC91AD29F9Q36894264-6D05198B-86D2-4FB6-8E58-665A5EFD3DDAQ37219819-4939084C-66FE-484E-89FE-79C354B9B8FEQ37339100-AD54E9B0-83C4-4F7E-8341-DC0B51516A53Q37583567-16167C87-6D48-4035-80CD-E7349F5A4920Q37636121-D66837F6-F1C3-4B26-BE03-1BFF27A7E1A4Q37643736-998001EF-6E31-4078-B5FB-AB028CE10B8CQ37722635-09F18942-96FD-4F0E-A054-1A3C1E033369Q37723880-B9ED403C-1185-4B8C-8E14-EC257145C102Q37867140-AFAAD503-C766-4BD5-B3F1-A67D0E36F11EQ37999086-EB706CA7-73C8-49E8-B3DF-250C514A5BFFQ38225912-D31B2374-B071-405D-9621-15948F15BBA5Q39337802-053E8C04-B2B3-406C-9F63-13B25DC197CEQ41198109-F4CB6E92-520A-4622-A6F7-82CE86586403Q42289715-9BB730E7-2875-4947-928A-7C67F57331B4Q44020460-84EAF5F0-8780-40D5-97C0-AEF8D897C40CQ46757500-E1C5594E-9A09-4723-90FF-7FF2488D0A79Q48473667-D7E4FFF8-988C-464F-B59C-CACE17006746Q50217150-63B09984-F455-4578-86F4-2681B707D854Q54967456-ED5EE604-6410-44DB-996A-CDB77F48D62F
P2860
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Deficiency of Aph1B/C-gamma-se ...... d with antipsychotic treatment
@nl
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@ast
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@en
type
label
Deficiency of Aph1B/C-gamma-se ...... d with antipsychotic treatment
@nl
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@ast
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@en
prefLabel
Deficiency of Aph1B/C-gamma-se ...... d with antipsychotic treatment
@nl
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@ast
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@en
P2093
P2860
P356
P1476
Deficiency of Aph1B/C-gamma-se ...... with antipsychotic treatment.
@en
P2093
A Herreman
B De Strooper
C Depboylu
D Alvarez-Fischer
G U Höglinger
J Van Biervliet
L Serneels
M K Schäfer
P2860
P304
P356
10.1073/PNAS.0800507105
P407
P577
2008-07-14T00:00:00Z