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Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexSequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growthRole of Notch signaling in regulating innate immunity and inflammation in health and diseaseThe involvement of microRNAs in neurodegenerative diseasesCharacterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cellsPresenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionAre we prepared to deal with the Alzheimer's disease pandemic?Presenilin controls CBP levels in the adult Drosophila central nervous system.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releaseMutagenesis mapping of the presenilin 1 calcium leak conductance pore.The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptorsRegulation of Ca2+ signaling with particular focus on mast cells.Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzymeLoss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged micePresenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cellsNOTCH pathway inactivation promotes bladder cancer progressionA role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.EpCAM and the biology of hepatic stem/progenitor cellsUpregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APPPresenilin 2 influences miR146 level and activity in microglia.Calcium signaling in trypanosomatid parasitesAn overview of notch signaling in adult tissue renewal and maintenance.Synaptic autoregulation by metalloproteases and γ-secretase.Expression of a naturally occurring angiotensin AT(1) receptor cleavage fragment elicits caspase-activation and apoptosis.ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor proteinNew pathway links γ-secretase to inflammation and memory while sparing notch.Notch signal suppresses Toll-like receptor-triggered inflammatory responses in macrophages by inhibiting extracellular signal-regulated kinase 1/2-mediated nuclear factor κB activation.Presenilin transgenic mice as models of Alzheimer's disease.Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.Effects of grape seed proanthocyanidin on Alzheimer's disease in vitro and in vivoTherapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERKSignaling from the secretory granule to the nucleus.Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase.Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage systemTranslocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration.The dyslexia-associated KIAA0319 protein undergoes proteolytic processing with {gamma}-secretase-independent intramembrane cleavage.Presenilin regulates insulin signaling via a gamma-secretase-independent mechanismIn vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Presenilin: RIP and beyond.
@en
Presenilin: RIP and beyond.
@nl
type
label
Presenilin: RIP and beyond.
@en
Presenilin: RIP and beyond.
@nl
prefLabel
Presenilin: RIP and beyond.
@en
Presenilin: RIP and beyond.
@nl
P2093
P2860
P1476
Presenilin: RIP and beyond.
@en
P2093
Chihiro Sato
Guojun Zhao
Matthew R Hass
Raphael Kopan
P2860
P304
P356
10.1016/J.SEMCDB.2008.11.014
P577
2008-11-27T00:00:00Z