Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor
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Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonistsIn vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide SNeuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdalaMolecular evolution of the neuropeptide S receptorStructure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptorIn vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma.Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.Neuropeptide S attenuates neuropathological, neurochemical and behavioral changes induced by the NMDA receptor antagonist MK-801.Behavioral phenotyping of neuropeptide S receptor knockout mice.Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activityImportance of extracellular loop one of the neuropeptide S receptor for biogenesis and functionNasal application of neuropeptide S inhibits arthritis pain-related behaviors through an action in the amygdala.Molecular fingerprint of neuropeptide S-producing neurons in the mouse brain.The asthma candidate gene NPSR1 mediates isoform specific downstream signalling.Identification of neuropeptide S antagonists: structure-activity relationship studies, X-ray crystallography, and in vivo evaluation.Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortexSelective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor.Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain.Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis.Effects of the neuropeptide S receptor antagonist RTI-118 on abuse-related facilitation of intracranial self-stimulation produced by cocaine and methylenedioxypyrovalerone (MDPV) in rats.Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivityNeuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathwaysIntranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats.Stress-related neuropeptides and addictive behaviors: beyond the usual suspects.Translational approach to develop novel medications on alcohol addiction: focus on neuropeptides.Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonistsNeuropeptide S: a transmitter system in the brain regulating fear and anxiety.Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery.Neuropeptide S receptor ligands: a patent review (2005-2016).Prevention of stress-impaired fear extinction through neuropeptide s action in the lateral amygdalaAnatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry.Neuropeptide S precursor knockout mice display memory and arousal deficits.GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.Neuropeptide-S evoked arousal with electroencephalogram slow-wave compensatory drive in rats.Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.Characterization of NGFFYamide Signaling in Starfish Reveals Roles in Regulation of Feeding Behavior and Locomotory Systems
P2860
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P2860
Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Synthesis and pharmacological ...... of the neuropeptide S receptor
@ast
Synthesis and pharmacological ...... of the neuropeptide S receptor
@en
Synthesis and pharmacological ...... of the neuropeptide S receptor
@nl
type
label
Synthesis and pharmacological ...... of the neuropeptide S receptor
@ast
Synthesis and pharmacological ...... of the neuropeptide S receptor
@en
Synthesis and pharmacological ...... of the neuropeptide S receptor
@nl
prefLabel
Synthesis and pharmacological ...... of the neuropeptide S receptor
@ast
Synthesis and pharmacological ...... of the neuropeptide S receptor
@en
Synthesis and pharmacological ...... of the neuropeptide S receptor
@nl
P2093
P2860
P356
P1476
Synthesis and pharmacological ...... of the neuropeptide S receptor
@en
P2093
A Richard Chamberlin
Joanne Zeng
Naoe Okamura
Rainer K Reinscheid
Stephen A Habay
P2860
P304
P356
10.1124/JPET.107.135103
P407
P577
2008-06-01T00:00:00Z