An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
about
Nedd4-2 and the regulation of epithelial sodium transportWNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathwayThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKsAngiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayWNK kinases, renal ion transport and hypertensionSerum and Glucocorticoid Regulated Kinase 1 in Sodium HomeostasisRoles of Akt and SGK1 in the Regulation of Renal Tubular TransportEpithelial Na(+) channel regulation by cytoplasmic and extracellular factorsThe role of the ENaC-regulatory complex in aldosterone-mediated sodium transportFGF23 promotes renal calcium reabsorption through the TRPV5 channelDisease-causing mutations in KLHL3 impair its effect on WNK4 degradationPOSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.Targeting SGK1 in diabetesAldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats.The physiological impact of the serum and glucocorticoid-inducible kinase SGK1Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosteroneRole of epithelial sodium channels and their regulators in hypertension.Concerted actions of NHERF2 and WNK4 in regulating TRPV5Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1.Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradationFirst WNK4-hypokalemia animal model identified by genome-wide association in Burmese cats.The WNKs: atypical protein kinases with pleiotropic actions.WNK4-mediated regulation of renal ion transport proteins.Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinaseSrc-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels.Enhanced phosphoserine insertion during Escherichia coli protein synthesis via partial UAG codon reassignment and release factor 1 deletion.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sitesMaintaining K+ balance on the low-Na+, high-K+ diet.WNK4 inhibits Ca(2+)-activated big-conductance potassium channels (BK) via mitogen-activated protein kinase-dependent pathwayWNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitinationRegulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epitheliumHypertension: the missing WNKs.Regulation of potassium (K) handling in the renal collecting duct.Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.
P2860
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P2860
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
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2007 թվականի մարտին հրատարակված գիտական հոդված
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2007年の論文
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2007年学术文章
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2007年学术文章
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name
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@ast
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@en
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@nl
type
label
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@ast
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@en
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@nl
prefLabel
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@ast
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@en
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@nl
P2093
P2860
P3181
P356
P1476
An SGK1 site in WNK4 regulates ...... e signaling and K+ homeostasis
@en
P2093
Aaron M Ring
Frederick H Wilson
Jesse Rinehart
Kristopher T Kahle
Qiang Leng
Richard P Lifton
Steven C Hebert
P2860
P304
P3181
P356
10.1073/PNAS.0611728104
P407
P577
2007-03-06T00:00:00Z