WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
about
Nedd4-2 and the regulation of epithelial sodium transportWNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathwayThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKsSerum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family membersAngiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayWNK kinases, renal ion transport and hypertensionAn SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasisRegulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.Epithelial Na(+) channel regulation by cytoplasmic and extracellular factorsChloride Sensing by WNK1 Involves Inhibition of AutophosphorylationHypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure.Regulation of with-no-lysine kinase signaling by Kelch-like proteins.Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.Comprehensive assessment of the association of WNK4 polymorphisms with hypertension: evidence from a meta-analysis.WNK kinases and renal sodium transport in health and disease: an integrated view.The WNKs: atypical protein kinases with pleiotropic actions.The Cap1-claudin-4 regulatory pathway is important for renal chloride reabsorption and blood pressure regulation.WNK4-mediated regulation of renal ion transport proteins.Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinaseKLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.Aquaporin-2: new mutations responsible for autosomal-recessive nephrogenic diabetes insipidus-update and epidemiology.Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.Potassium excretion during antinatriuresis: perspective from a distal nephron model.Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice.Cell-specific regulation of L-WNK1 by dietary K.Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sitesAn unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitinationRegulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epitheliumLong-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome.Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.Role of BK channels in hypertension and potassium secretion.Aldosterone paradox: differential regulation of ion transport in distal nephron.Independent regulation of Na+ and K+ balance by the kidney.WNK3 is a putative chloride-sensing kinase.WNK kinases and the kidney.Advances in WNK signaling of salt and potassium metabolism: clinical implications.Pathophysiology of salt sensitivity hypertension.
P2860
Q21129256-9A7AAC2F-6F68-4171-947C-0778709F0F72Q24310130-B6F9C5A2-7F74-41D3-A871-C079E221AF6AQ24623288-734371D9-8091-4EE1-954E-5FC08700D255Q24633684-885BA9F2-14CA-4393-8554-9C42CBDC51D0Q24648927-38227392-023D-4C7F-9D03-01B7AA6CF80DQ24649138-B087D079-3AA3-446A-8F50-74048B05F3BAQ24669948-55A2664F-35B2-4AB2-9777-D71970AA4964Q26770258-7FF22C88-7233-4FE0-959B-90911006C07BQ26825006-E7E1F1CC-5053-42B5-A7B7-32A6DCF826D0Q27683663-47325E6A-1FFA-4E5E-9792-3166CF5D1CE9Q33799953-8CAA3B98-F4F3-4444-ABDB-9BC82F989F44Q34174710-4E3BA7B0-3B7C-40F2-8420-FF9FED5D5077Q34241490-0C6BAE70-A886-4D89-9B7C-EA3CA43F104FQ34330710-55B8C4FA-6ABC-4451-89BB-795B5564CB8EQ34548846-13463933-4989-46D7-AF25-21BDFD42031DQ34560188-8420C25B-17A4-4BCB-BB6B-8E36728E1878Q34583490-1A48779E-EEA2-437F-9C08-7EFC4FFE10DCQ34651613-F88C4562-D0E5-482B-A2ED-FD90968E5CA0Q35274006-C8E3D604-76F6-438B-985F-22F41529F8AEQ35378646-6E1FBA24-17F6-40E7-823F-011C9E54BF3DQ35452558-D92EEE16-8CEF-49F9-9CEF-888F7BD60006Q35754537-DB152A88-977C-4740-9180-C31F2584506AQ35849478-A1DE8371-C1BF-4887-9677-8A753809FD71Q35974133-CAC9295D-C9C3-4261-A2CA-E5543BD5D6E5Q36192473-0B87F9A7-EFF5-4672-93D9-2031689E7B45Q36363337-AB5012AF-F266-4987-9789-A60F61EF1784Q36527855-AFC2A5A6-8EDA-4A55-AD7B-DC2F0C843A2BQ36817088-0C5CE164-6290-4587-96A7-36947E8AF027Q36877860-B5914DF7-B4CB-4088-9527-CD56B297EAEBQ37051467-9B3E3FF4-59C5-44B8-BEB7-675554C9E775Q37139042-556EB6F7-44D7-437F-8F03-B624842FD63FQ37310454-899F8F7A-D24D-48DB-8A03-403C23A3CB2DQ37328447-BBD5D0B2-29C0-402D-A99C-CAEC7CAAFD48Q37339906-D2218E99-6A44-4C37-B69C-87192B63B6CAQ37864472-F859FA47-83F6-401F-9E89-AD4DBDCCD0A6Q37951339-67A2841F-92AE-4028-9F21-6A416E3AEB1CQ37969554-3BD75C11-70BA-4CC0-9C1C-5B2E76A13C30Q37992360-1021FAAE-F2E9-4E6B-B8C0-E4F0B9C518E6Q38003087-891D7F74-6030-4C2C-B553-CF1FB940C2D2Q38019993-49997D73-2BDD-409A-90B1-37512EB3846C
P2860
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@ast
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@en
type
label
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@ast
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@en
prefLabel
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@ast
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.
@en
P2093
P2860
P356
P1476
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo
@en
P2093
Frederick H Wilson
Heather M Volkman
Jesse Rinehart
Kristopher T Kahle
Maria D Lalioti
Qiang Leng
Richard P Lifton
Sam X Cheng
Steven C Hebert
P2860
P304
P356
10.1073/PNAS.0611727104
P407
P50
P577
2007-02-26T00:00:00Z