Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients - Wikidata - wikimedia - TriplyDB

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

http://www.wikidata.org/entity/Q24670250

about

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy Histone methyltransferases: novel targets for tumor and developmental defects Partners in crime: The role of tandem modules in gene transcription Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition Identification of ID-1 as a potential target gene of MMSET in multiple myeloma A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression.A Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex MMSET: role and therapeutic opportunities in multiple myeloma.New strategies in the treatment of multiple myeloma.Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Microfluidic chips for detecting the t(4;14) translocation and monitoring disease during treatment using reverse transcriptase-polymerase chain reaction analysis of IgH-MMSET hybrid transcripts The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell-based immunotherapy Genetic events in the pathogenesis of multiple myeloma.The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells.Clinical implications of chromosomal abnormalities in multiple myeloma.Multiple-myeloma-related WHSC1/MMSET isoform RE-IIBP is a histone methyltransferase with transcriptional repression activity.Ten years and counting: so what do we know about t(4;14)(p16;q32) multiple myeloma.Review of molecular diagnostics in multiple myeloma.The genetic and genomic background of multiple myeloma patients achieving complete response after induction therapy with bortezomib, thalidomide and dexamethasone (VTD)Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas.Plasma membrane proteomics identifies biomarkers associated with MMSET overexpression in T(4;14) multiple myeloma.PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks.Understanding the language of Lys36 methylation at histone H3.AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis.Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics.Understanding the molecular biology of myeloma and its therapeutic implications.Molecular diagnostics of non-Hodgkin lymphoma.Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination An open and shut case for the role of NSD proteins as oncogenes.The NSD family of protein methyltransferases in human cancer.MMSET regulates expression of IRF4 in t(4;14) myeloma and its silencing potentiates the effect of bortezomib.H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication.

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P2860

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

http://www.wikidata.org/entity/Q24670250

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2005 nî lūn-bûn

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2005年の論文

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Overexpression of transcripts ...... tive multiple myeloma patients

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Andrew R Belch

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Brian J Taylor

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Linda M Pilarski

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Loree M Larratt

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Marta Chesi

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Michael J Mant

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P Leif Bergsagel

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Tony Reiman

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P2860

Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma

SMART, a simple modular architecture research tool: identification of signaling domains

The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds

Rapid exchange of histone H1.1 on chromatin in living human cells

A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts

Chromosome translocations in multiple myeloma

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains an IGH/MMSET fusion transcript

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Michael J. Hendzel

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