75 years of opioid research: the exciting but vain quest for the Holy Grail - Wikidata - wikimedia - TriplyDB

75 years of opioid research: the exciting but vain quest for the Holy Grail

75 years of opioid research: the exciting but vain quest for the Holy Grail

http://www.wikidata.org/entity/Q24670315

about

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling The mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injury Opioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminase Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS)Salvinorin A analogs as probes in opioid pharmacology.Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.The effects of opioids and opioid analogs on animal and human endocrine systems Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.Operant nociception in nonhuman primates.Morphine regulates dopaminergic neuron differentiation via miR-133b.μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.Opioids and the treatment of chronic pain: controversies, current status, and future directions.Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo.Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats.Neuropsychological Functions of μ- and δ-Opioid Systems.MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.Engineering endomorphin drugs: state of the art.Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.Rare diseases and orphan drugs.Pharmacology of nonsteroidal antiinflammatory drugs and opioids Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo Endomorphin-2: a biased agonist at the μ-opioid receptor.The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?Morphine and microRNA Activity: Is There a Relation with Addiction?Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents.Tolerance to the antinociceptive and hypothermic effects of morphine is mediated by multiple isoforms of c-Jun N-terminal kinase.Neoclerodanes as atypical opioid receptor ligands

P2860

Q24302002-B54470DC-E14F-49B3-8785-19A1800B4040 Q26999066-ADB143E1-3108-48ED-8FA4-2FD5CFE1C38A Q27027736-66F4742A-4467-4214-B769-B5FA51D435AD Q27303730-FC33752A-0596-460B-9582-2EEF263FC602 Q28541234-8CE63D4F-1CE6-46E8-ADD1-E02C5C2D780B Q28581321-6E9A3BAC-2793-4D05-AE46-6CE162EB0CB7 Q28652508-85DA36BD-298C-450D-9DA6-925C1EEA31AE Q30439719-C887531E-135F-4451-8C78-CBC46526ADEC Q30841944-5F386B45-93E7-44F8-A614-16C0A6E62AE4 Q33333352-FBBBF584-D698-4D36-937E-E4456C7216A8 Q33643208-264F1E53-1A30-4349-A5A0-B3671B607F06 Q33779667-3B1B8145-BCB6-447C-B8AA-D4A93A8E0C64 Q33802867-A43CA567-7DBE-45F1-A56E-ECD16623B6F4 Q33875900-A72738B1-63F5-4CEE-AEA3-5F3F64C04C03 Q34073200-65525774-E72B-4551-918A-E0F99B26CF81 Q34150516-97938FE5-5D7A-464A-ABB2-1C8B37C67AE4 Q34309942-75693F93-94B5-4F9F-BC18-52B3415CE2FF Q34310081-68373D85-1B90-42C1-8B5A-57517A43EB94 Q34574285-7792283F-AA93-4584-86AE-B44D4F9F465A Q34846394-E466F72E-9077-4175-8D5D-334DF1E40496 Q34939590-0F154A72-DE8F-41DD-A000-015C80A24CA5 Q35077913-1252F016-2E6C-4C7F-8FC6-7BF19D8185FD Q35166507-D05546C6-9CF6-4DB7-BB38-16C2895DEC64 Q35361350-10559FE4-74F9-45F3-BD6D-A3360D2A2443 Q35545574-B4A0A412-B3B4-4A41-A049-9C0F70AC81AA Q35660653-75B0174A-E6AF-4E9E-BBFE-B580FD57043B Q35684498-8E62A2F0-F4FE-4144-A345-4A5D21FF2E6B Q35736611-74003B5A-B9C8-491C-97E9-D1D4E481A0C0 Q35827448-711ACC6B-CE03-4040-9975-DA46AB9D3B67 Q35882922-7CFCD028-A1F0-407A-AF98-E7B66B521978 Q35989689-A87BDAE8-0BA3-4132-9ADB-7AC980C5DBD4 Q36105355-66A22424-2F9F-4201-95EA-B17620E186F4 Q36105495-83A0765E-4A82-4EC1-9027-09FE3547EBC3 Q36110480-2A18B4D9-7B9B-4F7C-971D-5228249E48ED Q36386234-6C18788B-F10B-4CBA-9BBF-74E1113D0664 Q36591603-24FD068B-5E7D-489E-A323-C4D27967621B Q36638633-9F6639CA-2476-4BD1-A619-9DBC151C1A56 Q36670065-FD92244F-F57B-4200-BA7C-7753F3910349 Q36730465-36A35C0C-257A-4739-A629-01FD44055FAE Q36899819-2074772A-C80D-4241-BFB9-B8D98C90C907

P2860

75 years of opioid research: the exciting but vain quest for the Holy Grail

http://www.wikidata.org/entity/Q24670315

description

2006 nî lūn-bûn

@nan

2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

name

75 years of opioid research: the exciting but vain quest for the Holy Grail

@ast

75 years of opioid research: the exciting but vain quest for the Holy Grail

@en

75 years of opioid research: the exciting but vain quest for the Holy Grail

@nl

type

label

75 years of opioid research: the exciting but vain quest for the Holy Grail

@ast

75 years of opioid research: the exciting but vain quest for the Holy Grail

@en

75 years of opioid research: the exciting but vain quest for the Holy Grail

@nl

prefLabel

75 years of opioid research: the exciting but vain quest for the Holy Grail

@ast

75 years of opioid research: the exciting but vain quest for the Holy Grail

@en

75 years of opioid research: the exciting but vain quest for the Holy Grail

@nl

P1433

Q24670315-FAE5341A-11BB-4E6D-AC07-1AF81518AEF8

P1476

Q24670315-091A7BEF-4706-4A1A-A699-EF439ED640D8

P2093

Q24670315-2E684AE8-6D39-4108-8091-94F523907F0A

Q24670315-3F2F41DE-F69B-4CE7-8B75-27128E79954B

Q24670315-492A345E-BBED-423B-BF03-197030143DC1

Q24670315-FDE08415-9E77-4E30-8A25-136DF943F041

P2860

Q24670315-086C9A55-26CE-4D2F-BDF7-9566CEAD3CB6

Q24670315-08D1EFFD-9B63-40D7-B468-104CAABFFDE4

Q24670315-08EFFB03-070C-421F-98B3-29EBEDA038F9

Q24670315-19A5DDF2-6AD0-4D0B-A119-DC329FB54B81

Q24670315-1BC3D8D6-57B7-4A46-88BA-E3FC837AE9F3

Q24670315-205AE458-F84E-4139-AD77-EC7FA983187E

Q24670315-3134F576-8819-4301-9594-DA24C2F3235C

Q24670315-3A120568-AA5F-4094-9993-568A3078E18C

Q24670315-3AC32DDF-5D48-4EB0-8058-B89C4380CF74

Q24670315-3D03B1A9-4C5E-4AF9-A3B8-8A8084438B96

P304

Q24670315-BC9D1FD3-E2D0-4174-ABC2-7187960FA1A6

P31

Q24670315-FD2D6350-1DE3-4386-B137-E5285392616B

P3181

Q24670315-DE3E158F-AB7C-4B1D-8E88-168D7E921476

P356

Q24670315-7A946E87-742B-497A-ADCD-A0843A75D9BF

P407

Q24670315-BFB3B30A-3D30-405F-BC4A-E406A39FB01A

P433

Q24670315-B2CB1F4B-0DBB-49CF-AFEF-1032B38D800B

P478

Q24670315-972D16D2-F6FC-4EFA-97BA-1461E2D223FC

P577

Q24670315-526B775E-B87E-414F-A832-4ED583F747FE

P5875

Q24670315-4F350E14-2CC8-46BE-BB10-9FFFE41B47BE

P698

Q24670315-8EC7A373-66AF-4CA8-A745-03E30A20424D

P921

Q24670315-720D38D6-228C-416A-8B48-B8C9E374866B

P932

Q24670315-4A866460-2DE0-43E2-9967-2D331B35ACE2

P3181

P356

P1433

British Journal of Pharmacology

P1476

75 years of opioid research: the exciting but vain quest for the Holy Grail

@en

P2093

Alexander T McKnight

http://www.w3.org/2001/XMLSchema#string

Alistair D Corbett

http://www.w3.org/2001/XMLSchema#string

Graeme Henderson

http://www.w3.org/2001/XMLSchema#string

Stewart J Paterson

http://www.w3.org/2001/XMLSchema#string

P2860

Behavioral effects of delta-opioid receptor agonists: potential antidepressants?

The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ

Cellular and synaptic adaptations mediating opioid dependence.

Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Opioid receptors.

Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome.

Synaptic plasticity and drug addiction.

Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking.

A potent and selective endogenous agonist for the mu-opiate receptor.

Analgesic effectiveness of the narcotic agonist-antagonists.

P304

S153-62

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2311106

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.BJP.0706435

http://www.w3.org/2001/XMLSchema#string

P407

P433

S1

http://www.w3.org/2001/XMLSchema#string

P478

147 Suppl 1

http://www.w3.org/2001/XMLSchema#string

P577

2006-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

7369979

http://www.w3.org/2001/XMLSchema#string

P698

16402099

http://www.w3.org/2001/XMLSchema#string

P921

P932

1760732

http://www.w3.org/2001/XMLSchema#string