μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization. - Wikidata - wikimedia - TriplyDB

μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.

μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.

http://www.wikidata.org/entity/Q34310081

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Novel GPCR paradigms at the μ-opioid receptor Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor.Loss of morphine reward and dependence in mice lacking G protein-coupled receptor kinase 5.Impact of efficacy at the μ-opioid receptor on antinociceptive effects of combinations of μ-opioid receptor agonists and cannabinoid receptor agonists.Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor Functionally selective signaling for morphine and fentanyl antinociception and tolerance mediated by the rat periaqueductal gray.Opioid receptor desensitization: mechanisms and its link to tolerance Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area Change in functional selectivity of morphine with the development of antinociceptive tolerance.Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception.Quantifying ligand bias at seven-transmembrane receptors.Phosphatidylethanolamine-binding protein is not involved in µ-opioid receptor-mediated regulation of extracellular signal-regulated kinase.Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation.Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human Time course of altered sensitivity to inhibitory and excitatory agonist responses in the longitudinal muscle-myenteric plexus and analgesia in the Guinea pig after chronic morphine treatment.Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.ßarrestin1-biased agonism at human δ-opioid receptor by peptidic and alkaloid ligands.Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.Endomorphin-2: a biased agonist at the μ-opioid receptor.Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults Modulating neuromodulation by receptor membrane traffic in the endocytic pathway.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.The role of kinetic context in apparent biased agonism at GPCRs.Differentiation of opioid drug effects by hierarchical multi-site phosphorylation Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.Propagation of conformational changes during μ-opioid receptor activation.Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.Reversal of morphine analgesic tolerance by ethanol in the mouse.

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μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.

http://www.wikidata.org/entity/Q34310081

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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μ-opioid receptors: correlatio ...... y to activate internalization.

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Molecular Pharmacology

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μ-opioid receptors: correlatio ...... y to activate internalization.

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Eamonn Kelly

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Graeme Henderson

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Jamie McPherson

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Javier Llorente

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Myma Baptist

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William L Dewey

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P2860

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

75 years of opioid research: the exciting but vain quest for the Holy Grail

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Qualitative and quantitative assessment of relative agonist efficacy

The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence

The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy

Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

Cellular and synaptic adaptations mediating opioid dependence.

Agonist-selective mechanisms of GPCR desensitization

Role of receptor internalization in opioid tolerance and dependence.

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10.1124/MOL.110.066613

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Guadalupe Rivero

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Cornelius Krasel

Suleiman Al-Sabah

Elizabeth M Rosethorne

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