Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay - Wikidata - wikimedia - TriplyDB

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

http://www.wikidata.org/entity/Q24671869

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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen Prolyl 4-hydroxylase Targeting Protein-Protein Interactions in the HIF System The Role of Oxygen Sensors, Hydroxylases, and HIF in Cardiac Function and Disease Epigenetic regulation by histone demethylases in hypoxia Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen Inhibition of 2-oxoglutarate dependent oxygenases HIF prolyl hydroxylase inhibitors for anemia Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes Substrate preference of the HIF-prolyl hydroxylase-2 (PHD2) and substrate-induced conformational change.Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model.Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.Human high-altitude adaptation: forward genetics meets the HIF pathway.Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases.Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.The rate-limiting step of O2 activation in the α-ketoglutarate oxygenase factor inhibiting hypoxia inducible factor.Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours.Nothing Iffy about HIF in the Hypothalamus.The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)Substrate Promotes Productive Gas Binding in the α-Ketoglutarate-Dependent Oxygenase FIH.Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1.Turn me on: regulating HIF transcriptional activity.Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2.

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

http://www.wikidata.org/entity/Q24671869

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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Studies on the activity of the ...... ng an oxygen consumption assay

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Studies on the activity of the ...... ng an oxygen consumption assay

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David N Genn

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Kirsty S Hewitson

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Nicolas Mathioudakis

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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227-34

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552552

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10.1042/BJ20061151

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1

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Peter J. Ratcliffe

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16952279

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