The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
about
A novel role for XIAP in copper homeostasis through regulation of MURR1Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosisUpstream regulatory role for XIAP in receptor-mediated apoptosisEffect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activationXIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 DimerizationCrystal Structure of the BIR1 Domain of XIAP in Two Crystal FormsStructures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitmentDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosisApoptosis: a review of programmed cell deathDendroaspis natriuretic peptide induces the apoptosis of cardiac muscle cells.The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo.Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.Cytokine-induced tumor suppressors: a GRIM storyHost insect inhibitor-of-apoptosis SfIAP functionally replaces baculovirus IAP but is differentially regulated by Its N-terminal leader.Regulation of apoptosis by ubiquitination.Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP.Antisense approaches in prostate cancer.The protein structures that shape caspase activity, specificity, activation and inhibition.The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac.Apoptosis-based therapies and drug targets.Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell deathAntisense therapy for cancer.The apoptosome: emerging insights and new potential targets for drug designTRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition.Regulation of apoptosis by XIAP ubiquitin-ligase activitySmall-molecule pan-IAP antagonists: a patent review.IAPS and ubiquitylation.Zinc-rich inhibitor of apoptosis proteins (IAPs) as regulatory factors in the epithelium of normal and inflamed airways.A critical assessment of the methodologies to investigate the role of inhibition of apoptosis in rodent hepatocarcinogenesis.The mystery of BCL2 family: Bcl-2 proteins and apoptosis: an update.Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo.Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP).Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line.IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesisXIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death.Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
P2860
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P2860
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@ast
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@en
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@nl
type
label
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@ast
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@en
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@nl
prefLabel
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@ast
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@en
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@nl
P2093
P2860
P50
P356
P1476
The anti-apoptotic activity of ...... nd caspase 9-interacting sites
@en
P2093
Anne M Verhagen
Joanne Chew
Miha Pakusch
P2860
P304
P356
10.1083/JCB.200108085
P407
P577
2002-04-01T00:00:00Z