IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis - Wikidata - wikimedia - TriplyDB

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

http://www.wikidata.org/entity/Q39927741

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Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association OTULIN restricts Met1-linked ubiquitination to control innate immune signaling IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains ARTS and Siah collaborate in a pathway for XIAP degradation Survivin: a unique target for tumor therapy Small-molecule SMAC mimetics as new cancer therapeutics IAPs: a central element in the NF-κB activating signaling pathway Backbone and side-chain 1H, 13C and 15N assignments of the ubiquitin-associated domain of human X-linked inhibitor of apoptosis protein Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway Molecular basis for specificity of the Met1-linked polyubiquitin signal Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.Oncogenic activation of NF-kappaB.Potential therapeutic benefits of strategies directed to mitochondria.Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-κB activation by disturbing the interaction of XIAP with RIP2.Dacarbazine and the agonistic TRAIL receptor-2 antibody lexatumumab induce synergistic anticancer effects in melanoma.Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis Human caspases: activation, specificity, and regulation HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization Analysis of expression, cellular localization, and function of three inhibitors of apoptosis (IAPs) from Litopenaeus vannamei during WSSV infection and in regulation of antimicrobial peptide genes (AMPs).Increase in retinal ganglion cells' susceptibility to elevated intraocular pressure and impairment of their endogenous neuroprotective mechanism by age.The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism.New molecular bridge between RelA/p65 and NF-κB target genes via histone acetyltransferase TIP60 cofactor.Inhibitor of apoptosis proteins as intracellular signaling intermediates.IAPs limit activation of RIP kinases by TNF receptor 1 during development.Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress XIAP mediates NOD signaling via interaction with RIP2 Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress XIAP as a ubiquitin ligase in cellular signaling.Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte.

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

http://www.wikidata.org/entity/Q39927741

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

IAPs contain an evolutionarily ...... cell survival and oncogenesis

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IAPs contain an evolutionarily ...... cell survival and oncogenesis.

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type

label

IAPs contain an evolutionarily ...... cell survival and oncogenesis

@en

IAPs contain an evolutionarily ...... cell survival and oncogenesis.

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prefLabel

IAPs contain an evolutionarily ...... cell survival and oncogenesis

@en

IAPs contain an evolutionarily ...... cell survival and oncogenesis.

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P1433

Nature Cell Biology

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IAPs contain an evolutionarily ...... cell survival and oncogenesis

@en

P2093

Lars Zender

http://www.w3.org/2001/XMLSchema#string

Maria Miasari

http://www.w3.org/2001/XMLSchema#string

Maurice Darding

http://www.w3.org/2001/XMLSchema#string

Paula C A da Fonseca

http://www.w3.org/2001/XMLSchema#string

Scott Lowe

http://www.w3.org/2001/XMLSchema#string

Tencho Tenev

http://www.w3.org/2001/XMLSchema#string

Wen Xue

http://www.w3.org/2001/XMLSchema#string

P2860

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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P304

1309-1317

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scholarly article

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10.1038/NCB1789

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11

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10

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Janusz Bujnicki

Mads Gyrd-Hansen

Marketa J Zvelebil

Massimo M Santoro

P577

2008-10-19T00:00:00Z

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23395254

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1045912113

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18931663

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2818601

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