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Pharmacology of nociceptin and its receptor: a novel therapeutic target

Pharmacology of nociceptin and its receptor: a novel therapeutic target

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Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): ligand-based analysis of structural factors influencing intrinsic activity at NOP Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801 Pathophysiology, Clinical Importance, and Management of Neurogenic Lower Urinary Tract Dysfunction Caused by Suprasacral Spinal Cord Injury The Useage of Opioids and their Adverse Effects in Gastrointestinal Practice: A Review Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents Pharmacological properties of nociceptin/orphanin FQ-induced stimulation and inhibition of cyclic AMP formation in distinct layers of rat olfactory bulb Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists.Memory-specific temporal profiles of gene expression in the hippocampus Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.Effects of nociceptin/orphanin FQ on rats with cathartic colon Low utility of plasma Nociceptin/orphanin FQ in the diagnosis of hepatocellular carcinoma.Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor.Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory.The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111.Pharmacological profile of nociceptin/orphanin FQ receptors.Drug dependence: neuropharmacology and management.Solution structure of nociceptin peptides.Comparison of the ORL1 receptor-mediated inhibition of noradrenaline release in human and rat neocortical slices Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors [Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.Nociceptin/orphanin FQ: actions within the brain.Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation.Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms.In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.

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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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2000 թվականի ապրիլին հրատարակված գիտական հոդված

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2000年の論文

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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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P2860

Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay

ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Nocistatin, a peptide that blocks nociceptin action in pain transmission

Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands

Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene

Cloning of a delta opioid receptor by functional expression

The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist

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