[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. - Wikidata - wikimedia - TriplyDB

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

http://www.wikidata.org/entity/Q35044357

about

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor.Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex The NOP (ORL1) receptor antagonist Compound B stimulates mesolimbic dopamine release and is rewarding in mice by a non-NOP-receptor-mediated mechanism.Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor Activities of mixed NOP and mu-opioid receptor ligands.Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats Antagonism of endogenous nociceptin/orphanin FQ inhibits infarction-associated ventricular arrhythmias via PKC-dependent mechanism in rats.Evidence that orphanin FQ mediates progesterone negative feedback in the ewe.Recently patented and promising ORL-1 ligands: where have we been and where are we going?Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor.Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress.Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.Beta-arrestin 2 rather than G protein efficacy determines the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands.The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries.Partial agonist behaviour depends upon the level of nociceptin/orphanin FQ receptor expression: studies using the ecdysone-inducible mammalian expression system.Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung.Nociceptin/orphanin FQ modulates motor behavior and primary motor cortex output through receptors located in substantia nigra reticulata.Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness.In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptor.Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.G-protein-coupled receptor-mediated MAPK and PI3-kinase signaling is maintained in Chinese hamster ovary cells after γ-irradiation.Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic

P2860

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P2860

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

http://www.wikidata.org/entity/Q35044357

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

[Nphe1,Arg14,Lys15]nociceptin- ...... ciceptin/orphanin FQ receptor.

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type

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[Nphe1,Arg14,Lys15]nociceptin- ...... ciceptin/orphanin FQ receptor.

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[Nphe1,Arg14,Lys15]nociceptin- ...... ciceptin/orphanin FQ receptor.

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British Journal of Pharmacology

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[Nphe1,Arg14,Lys15]nociceptin- ...... ociceptin/orphanin FQ receptor

@en

P2093

Anna Rizzi

http://www.w3.org/2001/XMLSchema#string

Daniela Rizzi

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Domenico Regoli

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Girolamo Calo

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Giuliano Marzola

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John McDonald

http://www.w3.org/2001/XMLSchema#string

Michele Morari

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Raffaella Bigoni

http://www.w3.org/2001/XMLSchema#string

Remo Guerrini

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Severo Salvadori

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P2860

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Pharmacology of nociceptin and its receptor: a novel therapeutic target

Highly potent nociceptin analog containing the Arg-Lys triple repeat

Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor.

Nociceptin/orphanin FQ receptor ligands.

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.

In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist.

4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.

P304

303-311

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scholarly article

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10.1038/SJ.BJP.0704706

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2

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136

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David G Lambert

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2002-05-01T00:00:00Z

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11360322

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12010780

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1573345

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