An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
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Gle1 functions during mRNA export in an oligomeric complex that is altered in human diseaseThe mRNA export factor Gle1 and inositol hexakisphosphate regulate distinct stages of translationInteraction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA.Mutations in mRNA export mediator GLE1 result in a fetal motoneuron diseaseInositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1.Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function.The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.Identification and analysis of LNO1-like and AtGLE1-like nucleoporins in plantsDeleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis.Cytoplasmic hGle1A regulates stress granules by modulation of translation.Gle1 is a multifunctional DEAD-box protein regulator that modulates Ded1 in translation initiationNucleocytoplasmic transport: integrating mRNA production and turnover with export through the nuclear poreA zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization.Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production.Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility.A mitotic nuclear envelope tether for Gle1 also impacts nuclear and nucleolar architecture.A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodiesInsights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis.Structure and Function of the Nuclear Pore Complex Cytoplasmic mRNA Export Platform.An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish (Danio rerio).A genomic glance at the components of the mRNA export machinery in Plasmodium falciparumA Kaposi's sarcoma virus RNA element that increases the nuclear abundance of intronless transcripts.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Nup42 and IP6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells.Survival beyond the perinatal period expands the phenotypes caused by mutations in GLE1.Structural and functional analysis of mRNA export regulation by the nuclear pore complex.Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.Control of CNS functions by RNA-binding proteins in neurological diseasesThe Impact of Post-transcriptional Control: Better Living Through RNA Regulons
P2860
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P2860
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
description
2003 nî lūn-bûn
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2003 թուականի Մարտին հրատարակուած գիտական յօդուած
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2003 թվականի մարտին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
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2003年論文
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2003年论文
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name
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export
@nl
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@ast
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@en
type
label
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export
@nl
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@ast
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@en
prefLabel
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export
@nl
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@ast
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@en
P2093
P2860
P356
P1476
An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
@en
P2093
Dianne M Barry
Eric R Griffis
Frederic Kendirgi
Maureen A Powers
Susan R Wente
P2860
P304
P356
10.1083/JCB.200211081
P407
P577
2003-03-01T00:00:00Z