A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization.
about
Gle1 functions during mRNA export in an oligomeric complex that is altered in human diseasePostage for the messenger: designating routes for nuclear mRNA exportmiR-153 regulates SNAP-25, synaptic transmission, and neuronal developmentRegulation of mRNA trafficking by nuclear pore complexes.Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophiesDeleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis.A structural and genotypic scaffold underlying temporal integration.Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype.Galanin regulates blood glucose level in the zebrafish: a morphological and functional study.Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system.Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway.A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodiesInsights into mRNA export-linked molecular mechanisms of human disease through a Gle1 structure-function analysis.The roles of the nuclear pore complex in cellular dysfunction, aging and disease.Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates.The importance of managing the patient and not the gene: expanded phenotype of GLE1-associated arthrogryposis.A homozygous I684T in GLE1 as a novel cause of arthrogryposis and motor neuron loss.Nup42 and IP6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells.Expansion of the GLE1-associated arthrogryposis multiplex congenita clinical spectrum.Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates.Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.
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P2860
A zebrafish model of lethal congenital contracture syndrome 1 reveals Gle1 function in spinal neural precursor survival and motor axon arborization.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A zebrafish model of lethal co ...... l and motor axon arborization.
@ast
A zebrafish model of lethal co ...... l and motor axon arborization.
@en
type
label
A zebrafish model of lethal co ...... l and motor axon arborization.
@ast
A zebrafish model of lethal co ...... l and motor axon arborization.
@en
prefLabel
A zebrafish model of lethal co ...... l and motor axon arborization.
@ast
A zebrafish model of lethal co ...... l and motor axon arborization.
@en
P2093
P2860
P921
P356
P1433
P1476
A zebrafish model of lethal co ...... l and motor axon arborization.
@en
P2093
Bruce Appel
Susan R Wente
P2860
P304
P356
10.1242/DEV.074344
P407
P577
2012-02-22T00:00:00Z