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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

http://www.wikidata.org/entity/Q24681806

about

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy Vanadate induction of NF-kB involves IkB kinase B and SAPK/ERK kinasa 1 in macrophages Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1 Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha IKK1-deficient mice exhibit abnormal development of skin and skeleton Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation.Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism Subdomain VIII is a specificity-determining region in MEKK1 Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease.Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.Qingfei Xiaoyan Wan alleviates asthma through multi-target network regulation ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48.An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF-kappaB by lysophosphatidic acid.Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex.Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway.

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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

http://www.wikidata.org/entity/Q24681806

description

1998 nî lūn-bûn

@nan

1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@ast

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@en

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@nl

type

label

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@ast

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@en

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@nl

prefLabel

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@ast

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@en

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@nl

P1433

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P356

PNAS.95.16.9319

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Proceedings of the National Academy of Sciences of the United States of America

P1476

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

@en

P2093

F S Lee

http://www.w3.org/2001/XMLSchema#string

L C Dang

http://www.w3.org/2001/XMLSchema#string

R T Peters

http://www.w3.org/2001/XMLSchema#string

T Maniatis

http://www.w3.org/2001/XMLSchema#string

P2860

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

Identification and characterization of an IkappaB kinase

P304

9319-24

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scholarly article

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10.1073/PNAS.95.16.9319

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P433

16

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259223618

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9689078

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P932

21336

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