EPI64 regulates microvillar subdomains and structure - Wikidata - wikimedia - TriplyDB

EPI64 regulates microvillar subdomains and structure

EPI64 regulates microvillar subdomains and structure

http://www.wikidata.org/entity/Q24682601

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The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner A pathway sensor for genome-wide screens of intracellular proteolytic cleavage A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells Phosphatidylinositol 4,5-bisphosphate clusters the cell adhesion molecule CD44 and assembles a specific CD44-Ezrin heterocomplex, as revealed by small angle neutron scattering Open conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scattering Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains.Large membrane domains in hair bundles specify spatially constricted radixin activation.Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization.Epithelial microvilli establish an electrostatic barrier to microbial adhesion ERM proteins at a glance TBC proteins: GAPs for mammalian small GTPase Rab?NHERF1/EBP50 is a new marker in colorectal cancer.Shaping the intestinal brush border The enterocyte microvillus is a vesicle-generating organelle EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.Ezrin regulates microvillus morphogenesis by promoting distinct activities of Eps8 proteins.Sorting of Clathrin-Independent Cargo Proteins Depends on Rab35 Delivered by Clathrin-Mediated Endocytosis MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells.PDZ interactions regulate rapid turnover of the scaffolding protein EBP50 in microvilli.The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation.Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics.Interactome analysis reveals ezrin can adopt multiple conformational states.The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.Rab35: GEFs, GAPs and effectors.EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice Modifiers of Prat, a de novo purine synthesis gene, in Drosophila melanogaster.Molecular Dynamics of the Association of L-Selectin and FERM Regulated by PIP2.All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.

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EPI64 regulates microvillar subdomains and structure

http://www.wikidata.org/entity/Q24682601

description

2006 nî lūn-bûn

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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

EPI64 regulates microvillar subdomains and structure

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EPI64 regulates microvillar subdomains and structure

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EPI64 regulates microvillar subdomains and structure

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type

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EPI64 regulates microvillar subdomains and structure

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EPI64 regulates microvillar subdomains and structure

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EPI64 regulates microvillar subdomains and structure

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prefLabel

EPI64 regulates microvillar subdomains and structure

@ast

EPI64 regulates microvillar subdomains and structure

@en

EPI64 regulates microvillar subdomains and structure

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P1433

Journal of Cell Biology

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EPI64 regulates microvillar subdomains and structure

@en

P2093

Abraham Hanono

http://www.w3.org/2001/XMLSchema#string

Anthony Bretscher

http://www.w3.org/2001/XMLSchema#string

Damien Garbett

http://www.w3.org/2001/XMLSchema#string

David N Chambers

http://www.w3.org/2001/XMLSchema#string

David Reczek

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP

The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain

ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells.

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins

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803-13

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scholarly article

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10.1083/JCB.200604046

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5

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175

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6653085

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17145964

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P932

2064679

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