Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene
about
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesisRole of single-stranded DNA in targeting REV1 to primer terminiREV1 is implicated in the development of carcinogen-induced lung cancer.Kinetic basis of nucleotide selection employed by a protein template-dependent DNA polymeraseSequential assembly of translesion DNA polymerases at UV-induced DNA damage sitesMolecular chaperone Hsp90 regulates REV1-mediated mutagenesis.Translesion DNA polymerases and cancerRAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damageRev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assemblyREV1 accumulates in DNA damage-induced nuclear foci in human cells and is implicated in mutagenesis by benzo[a]pyrenediolepoxide.Translesion synthesis polymerases in the prevention and promotion of carcinogenesis.Analyses of ultraviolet-induced focus formation of hREV1 protein.
P2860
Q24794355-C7C6AD06-16B4-47DC-A973-36DA1F3BD1E2Q28248779-2B0690AB-0E97-496E-8E1D-B8A69F0B36F0Q33403696-F247BA28-D705-43C3-A55A-4C26B76517D1Q34009370-F78FE16F-B532-4843-99E7-CB55098A44F0Q35083472-C89F91CD-5CAA-46D0-B381-D73910B4A879Q35139973-5E1B9ECD-A487-4181-BA1A-8C4C1892BE08Q36210704-79C37D0A-0394-479D-A9CE-C79BAD294BCEQ37029552-F78E4850-0342-4EB3-8157-24CB60C7C547Q37507628-170B1D6C-98BC-4D1E-9ECD-A9CE33D5E953Q38063711-55EBFC9C-7F6B-4481-A204-98A6ACC7E071Q38703688-FFF4B95C-FA99-41E9-B5CF-C3F2BE07F9E9Q39986749-029412E6-48EB-4157-BAF8-6A9F7CB4E951Q40404762-D17F5510-0C09-4305-8BD5-B39A0B23632AQ42419243-D91514AC-F83B-4F82-9822-0EDC3D7F0CE4Q53636260-84D35B59-EDDE-4AD6-888B-0C68A8DD91C5
P2860
Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@ast
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@en
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@nl
type
label
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@ast
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@en
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@nl
prefLabel
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@ast
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@en
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@nl
P2093
P2860
P3181
P356
P1476
Ribozyme-mediated REV1 inhibit ...... tations in the human HPRT gene
@en
P2093
Denise R Clark
Luminita Panaitescu
W Glenn McGregor
Wolfgang Zacharias
P2860
P304
P3181
P356
10.1093/NAR/GKG725
P407
P577
2003-09-01T00:00:00Z