about
Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid TumorsTransition-state destabilization reveals how human DNA polymerase β proceeds across the chemically unstable lesion N7-methylguanineMolecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancerN-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases.Evidence for APOBEC3B mutagenesis in multiple human cancers"Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Translesion polymerase genes polymorphisms and haplotypes influence survival of osteosarcoma patients.Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.DNA damage tolerance: a double-edged sword guarding the genomeThe DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.Anti-apoptotic phenotypes of cholestan-3β,5α,6β-triol-resistant human cholangiocytes: characteristics contributing to the genesis of cholangiocarcinoma.DNA polymerase iota (Pol ι) promotes invasion and metastasis of esophageal squamous cell carcinoma.Chromosomal Rearrangements in Cancer: Detection and potential causal mechanisms.Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level.Translesion DNA polymerases in eukaryotes: what makes them tick?Error-prone DNA polymerase and oxidative stress increase the incidences of A to G mutations in tumors.Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases η and κ and Rev1 in error-prone translesion synthesis.DNA polymerase η mutational signatures are found in a variety of different types of cancer.Computational Simulations of DNA Polymerases: Detailed Insights on Structure/Function/Mechanism from Native Proteins to Cancer Variants.Polymorphisms in translesion polymerase genes influence treatment outcome in malignant mesothelioma.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Translesion DNA polymerases and cancer
@ast
Translesion DNA polymerases and cancer
@en
type
label
Translesion DNA polymerases and cancer
@ast
Translesion DNA polymerases and cancer
@en
prefLabel
Translesion DNA polymerases and cancer
@ast
Translesion DNA polymerases and cancer
@en
P2860
P356
P1476
Translesion DNA polymerases and cancer
@en
P2093
Nick M Makridakis
P2860
P356
10.3389/FGENE.2012.00174
P577
2012-09-06T00:00:00Z