Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase - Wikidata - wikimedia - TriplyDB

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

http://www.wikidata.org/entity/Q24685243

about

Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways Dynorphin, stress, and depression Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2 Kappa-opioid ligands in the study and treatment of mood disorders Role of kappa-opioid receptors in stress and anxiety-related behavior.Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Kappa opioid receptor contributes to EGF-stimulated neurite extension in development Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling.Behavioral stress may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms The role of kappa-opioid receptor activation in mediating antinociception and addiction.Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice.Differential expression and sensitivity of presynaptic and postsynaptic opioid receptors regulating hypothalamic proopiomelanocortin neurons.κ-Opioid receptors are not necessary for the antidepressant treatment of neuropathic pain Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity.The delta opioid receptor: an evolving target for the treatment of brain disorders.Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.A Double-Blind, Placebo-Controlled Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single, Escalating Oral Doses of JDTic.Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.Maturational alterations in constitutive activity of medial prefrontal cortex kappa-opioid receptors in Wistar rats Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.Ligand-directed signalling within the opioid receptor family.Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells.Therapeutic potential of β-arrestin- and G protein-biased agonists.Kinase cascades and ligand-directed signaling at the kappa opioid receptor.

P2860

Q24634808-558F9A34-D772-456C-8C4D-D608F1BE41F8 Q24643003-1E2828DF-95AE-470A-80A6-F4CB0452A91F Q24650168-45674A28-2C8A-4E7C-BA3D-EB53C23654C9 Q24653810-6CF939AA-D8A7-496D-A1A2-1AC58E5FB65E Q24657982-9E13B7A1-45A0-45DF-913E-3A1D7CFED9D3 Q26991739-E7BA8CDB-66E1-4CF9-AC9E-B525820B64CC Q27317766-E005491A-9F56-44EE-AE5E-7E58B3BF2EDA Q28267475-882B7E20-8798-4682-8FD3-B97C0FF6EB4B Q28275440-94795734-2A4D-4451-9B68-B9BC2F2FA8EF Q28580222-46B64985-3A97-4283-A1D6-6B06959EC864 Q30486707-96AE2C95-C573-4888-9583-C8E1CA6B9249 Q30491620-C2941336-95A8-453D-BBEC-191ACF49B5B6 Q30565476-96E35A3E-9EFE-4B31-B7E3-6395AA334251 Q33558914-D759989A-656A-42CA-BC85-BD9E534822E9 Q33733621-2C29F70E-08DE-4334-9BA3-770336778D75 Q33861304-B5B48477-CE4C-4BE1-823F-912DCA00DACA Q33952880-2748EF6F-D963-44A0-B75A-A09F93CECECF Q33998470-EF1BA837-1D65-4310-8F59-191D8B561ABB Q34132638-B53E7E7D-6FD7-473D-81A4-EC0081201C01 Q34285100-50A37584-B005-4218-9A2E-EEB2F66A6C12 Q34366661-3FCB0D6E-B453-4306-85EC-F8A93DEFFE90 Q34423181-7CBB5288-249B-4058-961D-6A462F5073A5 Q34701724-6ABE941E-F611-4611-A969-B909C9A10390 Q35039212-92BAC52F-30C1-442E-9C87-89836D74D2E8 Q35147542-BB13D34D-EC45-4EF6-AB4C-D3DC971F30FF Q35269480-9553E91F-69EB-4A0E-9895-58AEDB88132C Q35400738-26F57498-4271-43EB-A60D-29E1237D08D1 Q35744300-6F4A1104-BDBE-47B1-9D7A-D5052B965E1E Q35822876-0924CABA-749D-46BD-BBC0-FEED03AAF198 Q35906830-EB109F8A-586E-4995-9C61-767128772475 Q36042441-EE739D75-B022-4F8B-841D-BDE6762D2F64 Q36184879-CE2F1788-A31F-4F5F-BFA6-B0722ACE6A76 Q36186182-5A1A93C6-FA87-4B1F-9228-5C7E5097CA5E Q36259485-C42ACB14-289D-4F45-B87E-02708A568303 Q36305030-FAECF782-F052-4AB6-9E0F-87E97DD85E7D Q36382935-1684C451-F9FF-4004-99D2-28E297AA89C9 Q36470824-74FE0976-96AA-4D22-AE5C-0C1D265E0F92 Q36771850-35A900A9-6A13-40F1-9249-2CCF9CC8527E Q36773331-B64C7FA0-0BC2-4175-94B3-2AE708EE3B26 Q36900733-D4890084-575D-490E-B762-89B23FD78B74

P2860

Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase

http://www.wikidata.org/entity/Q24685243

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年学术文章

@wuu

2007年学术文章

@zh-cn

2007年学术文章

@zh-hans

2007年学术文章

@zh-my

2007年学术文章

@zh-sg

2007年學術文章

@yue

name

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@ast

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@en

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@nl

type

label

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@ast

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@en

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@nl

prefLabel

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@ast

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@en

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@nl

P1433

Q24685243-A437745D-6791-4A10-A277-6E111B63D696

P1476

Q24685243-C793EBD7-9415-4981-86BA-FC371C2CB5CF

P2093

Q24685243-1734D3D0-71F8-4C05-B823-27CE8EBE2BDA

Q24685243-478298B0-5F39-4FDC-9DC3-3E713F7E3C9B

Q24685243-57CACA23-411E-4841-87C2-DBDC28FFB1CF

Q24685243-58900E94-FFD1-431E-A6DD-32C617ACFFEF

Q24685243-5F053431-5AC0-4486-927B-D486410811E1

Q24685243-B6B761CE-0D30-4D31-BC33-2E66C4D2233A

Q24685243-CB5E1B5B-2246-4C10-B34A-9F2E2F114B6A

P2860

Q24685243-008189CE-8BDA-4FD9-8D87-CBE6399386FF

Q24685243-10073B5D-2EE7-4B98-93D2-A57F48CADFF4

Q24685243-10D06E3A-BA9E-4493-B355-0C5781E92C5F

Q24685243-121E79DF-2D4F-4D5F-8EB1-55AD3694AB95

Q24685243-157D7183-55C4-4D00-8D3A-9A3EFA3379E8

Q24685243-1696CA5B-4069-4D27-8CB1-270E5D22E3C1

Q24685243-1A1E918A-9E40-43D4-931D-9BE1CD546921

Q24685243-28A991BA-D609-4E49-BDEC-8AAED44AB23E

Q24685243-2B6FCD65-359E-4EDE-9227-00D65144AE5B

Q24685243-3BA0E4B6-1B84-483E-A121-E86592A56CBF

P304

Q24685243-24D46952-2DF3-4C5D-92A8-4ED2D5EAC817

P31

Q24685243-C9AE4C01-AB18-46C0-90E2-DE7C21DC948D

P356

Q24685243-67486B3A-6C5A-4DC2-B258-67B24485001E

P407

Q24685243-B336450E-C53C-4BFD-8042-869A73F552F3

P433

Q24685243-89F0D1A2-7332-49BD-B1B7-1EEEAD7658EA

P478

Q24685243-922D9CAB-F3F1-4D26-B3E1-C533380A392E

P577

Q24685243-854DE777-7E82-464B-83FA-06F95A8B19E0

P5875

Q24685243-64FCF1CB-18A5-4380-9930-85A00C3C7BD1

P698

Q24685243-9D31000E-6988-48FC-B916-566439608455

P921

Q24685243-16054289-CC49-496F-901B-027E855D0788

Q24685243-CF8CB3B7-D944-4FA1-BE97-266E832D47B8

P932

Q24685243-A1DB84DC-3FE3-4061-BCF6-EE83B9A9B3EA

P356

P1433

Journal of Biological Chemistry

P1476

Long-acting kappa opioid antag ...... vating c-Jun N-terminal kinase

@en

P2093

Charles Chavkin

http://www.w3.org/2001/XMLSchema#string

Mia Defino

http://www.w3.org/2001/XMLSchema#string

Michael R Bruchas

http://www.w3.org/2001/XMLSchema#string

Selena Schreiber

http://www.w3.org/2001/XMLSchema#string

Shuang Li

http://www.w3.org/2001/XMLSchema#string

Steven C Kwan

http://www.w3.org/2001/XMLSchema#string

Tao Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes

Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade

Kappa opioid antagonists: past successes and future prospects

Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses

Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes

Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells

Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization

P304

29803-11

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M705540200

http://www.w3.org/2001/XMLSchema#string

P407

P433

41

http://www.w3.org/2001/XMLSchema#string

P478

282

http://www.w3.org/2001/XMLSchema#string

P577

2007-10-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6136538

http://www.w3.org/2001/XMLSchema#string

P698

17702750

http://www.w3.org/2001/XMLSchema#string

P921

P932

2096775

http://www.w3.org/2001/XMLSchema#string