Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes
about
Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathwaysDynorphin, stress, and depressionRepeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid systemStress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinaseLong-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinaseAnalyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsMultifaceted role of β-arrestins in inflammation and diseaseFunctional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonistsRole of kappa-opioid receptors in stress and anxiety-related behavior.Peripheral sensitization increases opioid receptor expression and activation by crotalphine in ratsKappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine NeuronsThe atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptorsEndogenous opiates and behavior: 200630 years of dynorphins--new insights on their functions in neuropsychiatric diseasesActivation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking.GRK3 suppresses L-DOPA-induced dyskinesia in the rat model of Parkinson's disease via its RGS homology domainOptodynamic simulation of β-adrenergic receptor signalling.Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitizationPhosphorylation of the mu-opioid receptor at tyrosine 166 (Tyr3.51) in the DRY motif reduces agonist efficacy.Kappa opioid receptor contributes to EGF-stimulated neurite extension in developmentEffects of kappa opioid receptors on conditioned place aversion and social interaction in males and femalesβ-Arrestin 2 negatively regulates Toll-like receptor 4 (TLR4)-triggered inflammatory signaling via targeting p38 MAPK and interleukin 10.The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activationThe role of kappa-opioid receptor activation in mediating antinociception and addiction.6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment.Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formationIdentification of novel functionally selective κ-opioid receptor scaffolds.Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells.Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analoguesArrestins regulate cell spreading and motility via focal adhesion dynamicsExploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats.The functional cycle of visual arrestins in photoreceptor cells.Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammationA novel method for analyzing extremely biased agonism at G protein-coupled receptors.Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways
P2860
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P2860
Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@ast
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@en
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@nl
type
label
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@ast
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@en
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@nl
prefLabel
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@ast
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@en
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@nl
P2093
P2860
P921
P356
P1476
Kappa opioid receptor activati ...... dent in neurons and astrocytes
@en
P2093
Charles Chavkin
Janet D Lowe
Michael R Bruchas
Tara A Macey
P2860
P304
P356
10.1074/JBC.M513640200
P407
P577
2006-06-30T00:00:00Z