Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins
about
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.Clustered DNA lesions containing 5-formyluracil and AP site: repair via the BER systemEfficient formation of the tandem thymine glycol/8-oxo-7,8-dihydroguanine lesion in isolated DNA and the mutagenic and cytotoxic properties of the tandem lesions in Escherichia coli cells.Apex1 can cleave complex clustered DNA lesions in cells.HO* radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases.Saccharomyces cerevisiae-based system for studying clustered DNA damages.Role of oxidatively induced DNA lesions in human pathogenesisEndogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells.Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survivalDelayed repair of radiation induced clustered DNA damage: friend or foe?DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB induction and conversion induced by gamma rays and helium ions.Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences.Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage.DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining.Processing of DNA damage clusters in human cells: current status of knowledge.The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.The formation of double-strand breaks at multiply damaged sites is driven by the kinetics of excision/incision at base damage in eukaryotic cells.Replication fork collapse is a major cause of the high mutation frequency at three-base lesion clustersCorrelation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion.The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation.Reduced repair capacity of a DNA clustered damage site comprised of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 2-deoxyribonolactone results in an increased mutagenic potential of these lesions.Radiation-mediated formation of complex damage to DNA: a chemical aspect overview.Increased mutability and decreased repairability of a three-lesion clustered DNA-damaged site comprised of an AP site and bi-stranded 8-oxoG lesions.Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage.Induction and repairability of DNA damage caused by ultrasoft X-rays: role of core events.The roles of specific glycosylases in determining the mutagenic consequences of clustered DNA base damage.Accelerated processing of solitary and clustered abasic site DNA damage lesions by APE1 in the presence of aqueous extract of Ganoderma lucidum.
P2860
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P2860
Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins
description
2005 nî lūn-bûn
@nan
2005 թուականին հրատարակուած գիտական յօդուած
@hyw
2005 թվականին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
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name
Processing of a complex multip ...... s and purified repair proteins
@ast
Processing of a complex multip ...... s and purified repair proteins
@en
Processing of a complex multip ...... s and purified repair proteins
@nl
type
label
Processing of a complex multip ...... s and purified repair proteins
@ast
Processing of a complex multip ...... s and purified repair proteins
@en
Processing of a complex multip ...... s and purified repair proteins
@nl
prefLabel
Processing of a complex multip ...... s and purified repair proteins
@ast
Processing of a complex multip ...... s and purified repair proteins
@en
Processing of a complex multip ...... s and purified repair proteins
@nl
P2093
P2860
P3181
P356
P1476
Processing of a complex multip ...... s and purified repair proteins
@en
P2093
Didier Gasparutto
Evelyne Sage
Grégory Eot-Houllier
Séverine Eon-Marchais
P2860
P304
P3181
P356
10.1093/NAR/GKI165
P407
P577
2005-01-01T00:00:00Z