Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling
about
Engineering GPCR signaling pathways with RASSLsModifying ligand-induced and constitutive signaling of the human 5-HT4 receptorOsteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass.Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formationRemote control of neuronal signaling.Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptorGs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation.Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia.Engineered GPCRs as tools to modulate signal transduction.Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors.Light- and drug-activated G-protein-coupled receptors to control intracellular signalling.Unparalleled control of neural activity using orthogonal pharmacogenetics.Employing novel animal models in the design of clinically efficacious GPCR ligands.
P2860
Q28289158-705ACED9-AD0A-4CF6-B288-78B8D75B7A70Q28472395-7143B772-3F3D-4067-95EE-2A1EFAE0F228Q30481229-20E285BF-57CA-4DB4-8AFA-96EA6AB10A7FQ33735917-40A762D3-1009-46DE-BDBE-3BF792FF9EF2Q34858531-AB23457E-CC63-460C-A350-CDF3BE9109CCQ35031675-4590B024-246D-4DBF-B663-C64F30A52EA5Q35156288-2225998B-3B8B-48A1-A8D3-6B7D47CD3600Q35579256-F093FC67-D13B-4043-A9DA-14CF15F8E8C9Q36316851-A7642161-93B2-4EC4-AA33-AA185F05E8A0Q36509788-A4FC8CC2-1E49-44C9-A2E6-6B284B17DFB1Q37346874-D610D465-DD4C-4052-A65C-B13378C1926FQ37411523-3269D286-FCD5-4217-B021-C1BFE2DB7BDDQ37805900-D2E38EA1-8E7E-4062-9719-2A27522F3033Q38034970-0CF785ED-D795-42EF-81CE-93AFDD50408EQ38200338-334E8FCD-6E68-4A8E-A9B9-1713AE48320F
P2860
Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling
description
2005 nî lūn-bûn
@nan
2005 թուականին հրատարակուած գիտական յօդուած
@hyw
2005 թվականին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
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name
Engineered G protein coupled r ...... sitization and acute signaling
@ast
Engineered G protein coupled r ...... sitization and acute signaling
@en
Engineered G protein coupled r ...... sitization and acute signaling
@nl
type
label
Engineered G protein coupled r ...... sitization and acute signaling
@ast
Engineered G protein coupled r ...... sitization and acute signaling
@en
Engineered G protein coupled r ...... sitization and acute signaling
@nl
prefLabel
Engineered G protein coupled r ...... sitization and acute signaling
@ast
Engineered G protein coupled r ...... sitization and acute signaling
@en
Engineered G protein coupled r ...... sitization and acute signaling
@nl
P2093
P2860
P356
P1433
P1476
Engineered G protein coupled r ...... sitization and acute signaling
@en
P2093
Bruce R Conklin
Heather H Elliott
Kimberly Scearce-Levie
Michael D Lieberman
P2860
P2888
P356
10.1186/1741-7007-3-3
P407
P577
2005-01-01T00:00:00Z
P5875
P6179
1008287219