Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation
about
Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history.Remote control of neuronal signaling.Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblastsConstitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.Increased Gs Signaling in Osteoblasts Reduces Bone Marrow and Whole-Body Adiposity in Male Mice.Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality.
P2860
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P2860
Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Ligand-mediated activation of ...... ases trabecular bone formation
@ast
Ligand-mediated activation of ...... ases trabecular bone formation
@en
type
label
Ligand-mediated activation of ...... ases trabecular bone formation
@ast
Ligand-mediated activation of ...... ases trabecular bone formation
@en
prefLabel
Ligand-mediated activation of ...... ases trabecular bone formation
@ast
Ligand-mediated activation of ...... ases trabecular bone formation
@en
P2093
P2860
P356
P1476
Ligand-mediated activation of ...... ases trabecular bone formation
@en
P2093
Alyssa Louie
Bruce R Conklin
Edward C Hsiao
Robert A Nissenson
Susan M Millard
Yong Huang
P2860
P304
P356
10.1210/ME.2009-0424
P577
2010-02-11T00:00:00Z