The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor
about
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingCongenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineagesNuclear transport, oxidative stress, and neurodegenerationStimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideumThe promise and perils of HDAC inhibitors in neurodegenerationHuntingtin: alive and well and working in middle managementNormal huntingtin function: an alternative approach to Huntington's diseaseUnbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolismDeletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinThe Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus.Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatusIs Huntingtin Dispensable in the Adult Brain?Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro.Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genusAge-associated chromatin relaxation is enhanced in Huntington's disease mice.Huntingtin facilitates polycomb repressive complex 2.Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's diseaseGenome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validationTherapeutic approaches to preventing cell death in Huntington diseaseDominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategyLongitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats.A huntingtin peptide inhibits polyQ-huntingtin associated defectsCategorizer: a tool to categorize genes into user-defined biological groups based on semantic similarityHD CAG-correlated gene expression changes support a simple dominant gain of function.Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14LCharacterization of the activities of the CpeY, CpeZ, and CpeS bilin lyases in phycoerythrin biosynthesis in Fremyella diplosiphon strain UTEX 481.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.Multiple pathways contribute to the pathogenesis of Huntington disease.NF-kappa B as a therapeutic target in neurodegenerative diseases.Drug targeting of dysregulated transcription in Huntington's diseaseHuntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function.Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent mannerMutant huntingtin and mitochondrial dysfunction.Adaptation to Blue Light in Marine Synechococcus Requires MpeU, an Enzyme with Similarity to Phycoerythrobilin Lyase Isomerases.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Huntington's disease, calcium, and mitochondria.
P2860
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P2860
The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The predominantly HEAT-like mo ...... al family transcription factor
@ast
The predominantly HEAT-like mo ...... al family transcription factor
@en
The predominantly HEAT-like mo ...... al family transcription factor
@nl
type
label
The predominantly HEAT-like mo ...... al family transcription factor
@ast
The predominantly HEAT-like mo ...... al family transcription factor
@en
The predominantly HEAT-like mo ...... al family transcription factor
@nl
prefLabel
The predominantly HEAT-like mo ...... al family transcription factor
@ast
The predominantly HEAT-like mo ...... al family transcription factor
@en
The predominantly HEAT-like mo ...... al family transcription factor
@nl
P2860
P3181
P356
P1433
P1476
The predominantly HEAT-like mo ...... al family transcription factor
@en
P2093
Hiroki Takano
P2860
P2888
P3181
P356
10.1186/1471-2202-3-15
P407
P577
2002-10-14T00:00:00Z
P5875
P6179
1052691881