Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner - Wikidata - wikimedia - TriplyDB

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

http://www.wikidata.org/entity/Q36981055

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Oligonucleotide therapeutic approaches for Huntington disease Long non-coding RNAs in nervous system function and disease 5-Hydroxymethylcytosine: A new player in brain disorders?Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Prions, amyloids, and RNA: Pieces of a puzzle.Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation.Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease.Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.A common gene expression signature in Huntington's disease patient brain regions.In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.Comparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks: implications in biological processes and functions.Huntington disease (chorea) in the middle East.Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments.Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.Evaluating the SERCA2 and VEGF mRNAs as Potential Molecular Biomarkers of the Onset and Progression in Huntington's Disease Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.Polyglutamine (polyQ) disorders: the chromatin connection.Extensive changes in DNA methylation are associated with expression of mutant huntingtin.Expression of RNAs Coding for Metal Transporters in Blood of Patients with Huntington's Disease An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.MeCP2: a novel Huntingtin interactor.

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P2860

Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

http://www.wikidata.org/entity/Q36981055

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Huntingtin modulates transcrip ...... polyglutamine-dependent manner

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type

label

Huntingtin modulates transcrip ...... polyglutamine-dependent manner

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prefLabel

Huntingtin modulates transcrip ...... polyglutamine-dependent manner

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P1433

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P356

JNEUROSCI.2126-08.2008

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Journal of Neuroscience

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Huntingtin modulates transcrip ...... polyglutamine-dependent manner

@en

P2093

Caroline L Benn

http://www.w3.org/2001/XMLSchema#string

Derek P DiRocco

http://www.w3.org/2001/XMLSchema#string

George J Yohrling

http://www.w3.org/2001/XMLSchema#string

Jang-Ho J Cha

http://www.w3.org/2001/XMLSchema#string

Karen N McFarland

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Tingting Sun

http://www.w3.org/2001/XMLSchema#string

P2860

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

Huntingtin contains a highly conserved nuclear export signal

SUMO modification of Huntingtin and Huntington's disease pathology

Polyglutamine expansion of huntingtin impairs its nuclear export

Interaction of Huntington disease protein with transcriptional activator Sp1

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

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10720-10733

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scholarly article

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10.1523/JNEUROSCI.2126-08.2008

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42

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28

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Timothy W. Clark

Ghazaleh Sadri-Vakili

Bérengère Bouzou

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2008-10-01T00:00:00Z

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18923047

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2586288

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