CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
about
Recent advances in mammalian protein productionDaedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectorsHP1gamma function is required for male germ cell survival and spermatogenesis.Ubiquitous expression of the rtTA2S-M2 inducible system in transgenic mice driven by the human hnRNPA2B1/CBX3 CpG island.Foamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome.BAC TG-EMBED: one-step method for high-level, copy-number-dependent, position-independent transgene expression.Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIIILong-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vectorIn utero therapy for congenital disorders using amniotic fluid stem cells.In vivo crystallization of human IgG in the endoplasmic reticulum of engineered Chinese hamster ovary (CHO) cells.Molecular-genetic imaging of cancer.Clinical applications of gene therapy for primary immunodeficiencies.Chromatin function modifying elements in an industrial antibody production platform--comparison of UCOE, MAR, STAR and cHS4 elements.Proteolytic cleavage of chemerin protein is necessary for activation to the active form, Chem157S, which functions as a signaling molecule in glioblastoma.Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells.A novel regulatory element (E77) isolated from CHO-K1 genomic DNA enhances stable gene expression in Chinese hamster ovary cellsCloning and Characterization of a Human Genomic Sequence that Alleviates Repeat-Induced Gene Silencing.Evaluating the expression profile and stability of different UCOE containing vector combinations in mAb-producing CHO cellsLentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.Using cell engineering and omic tools for the improvement of cell culture processes.Organ targeted prenatal gene therapy--how far are we?The chromatin backdrop of DNA replication: lessons from genetics and genome-scale analyses.Proteins improving recombinant antibody production in mammalian cells.Ubiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification.Epigenetic regulatory elements: Recent advances in understanding their mode of action and use for recombinant protein production in mammalian cells.Epigenetic regulatory elements associate with specific histone modifications to prevent silencing of telomeric genes.Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins.The CpG-sites of the CBX3 ubiquitous chromatin opening element are critical structural determinants for the anti-silencing function.Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter.Assessment of UCOE on Recombinant EPO Production and Expression Stability in Amplified Chinese Hamster Ovary Cells.Evaluating the interaction between UCOE and DHFR-linked amplification and stability of recombinant protein expression.A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.PhiC31 integrase-mediated genomic integration and stable gene expression in the mouse mammary gland after gene electrotransfer.Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicingPhysiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells.The use of a stringent selection system allows the identification of DNA elements that augment gene expression.Desmin-regulated lentiviral vectors for skeletal muscle gene transfer.A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectorsEx vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells.
P2860
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P2860
CpG-island fragments from the HNRPA2B1/CBX3 genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
description
2005 nî lūn-bûn
@nan
2005 թուականին հրատարակուած գիտական յօդուած
@hyw
2005 թվականին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
CpG-island fragments from the ...... er/enhancer in mammalian cells
@ast
CpG-island fragments from the ...... er/enhancer in mammalian cells
@en
CpG-island fragments from the ...... er/enhancer in mammalian cells
@nl
type
label
CpG-island fragments from the ...... er/enhancer in mammalian cells
@ast
CpG-island fragments from the ...... er/enhancer in mammalian cells
@en
CpG-island fragments from the ...... er/enhancer in mammalian cells
@nl
prefLabel
CpG-island fragments from the ...... er/enhancer in mammalian cells
@ast
CpG-island fragments from the ...... er/enhancer in mammalian cells
@en
CpG-island fragments from the ...... er/enhancer in mammalian cells
@nl
P2093
P2860
P3181
P356
P1433
P1476
CpG-island fragments from the ...... er/enhancer in mammalian cells
@en
P2093
Alistair Irvine
Andrew Mountain
David Simpson
Mark Griffiths
Michael Antoniou
Robert Crombie
Steven Williams
Tony Mulcahy
Tracey Mustoe
P2860
P2888
P3181
P356
10.1186/1472-6750-5-17
P407
P577
2005-01-01T00:00:00Z
P5875
P6179
1036186635