Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
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Hematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsRecent advances in mammalian protein productionRecent progress in satellite cell/myoblast engraftment -- relevance for therapyDiscovery of a protective Rickettsia prowazekii antigen recognized by CD8+ T cells, RP884, using an in vivo screening platformThe GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgeneDaedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectorsLent-On-Plus Lentiviral vectors for conditional expression in human stem cellsLong-distance effects of insertional mutagenesisLentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vectorFoamy virus vector-mediated gene correction of a mouse model of Wiskott-Aldrich syndrome.Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates.Gene therapy for PIDs: progress, pitfalls and prospectsc-MycERTAM transgene silencing in a genetically modified human neural stem cell line implanted into MCAo rodent brainA functional screen for regulatory elements that improve retroviral vector gene expressionLentiviral vector transduction of spermatozoa as a tool for the study of early development.B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.Effect of different UCOE-promoter combinations in creation of engineered cell lines for the production of Factor VIIILong-term reproducible expression in human fetal liver hematopoietic stem cells with a UCOE-based lentiviral vectorA self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.Gammaretroviral vectors: biology, technology and applicationThe impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells.In utero therapy for congenital disorders using amniotic fluid stem cells.Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells.Human involucrin promoter mediates repression-resistant and compartment-specific LEKTI expressionStrategies to insulate lentiviral vector-expressed transgenesAlpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host diseaseCorrection of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene.Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.Overnight transduction with foamyviral vectors restores the long-term repopulating activity of Fancc-/- stem cells.Insertional gene activation by lentiviral and gammaretroviral vectors.Recent advances in gene therapy for severe congenital immunodeficiency diseasesDevelopment of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency.Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfectionLentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I.Lentiviral vectors for immune cells targeting.
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P2860
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 April 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Lentiviral vectors containing ...... ession in hematopoietic cells.
@en
Lentiviral vectors containing ...... ting chromatin opening element
@nl
type
label
Lentiviral vectors containing ...... ession in hematopoietic cells.
@en
Lentiviral vectors containing ...... ting chromatin opening element
@nl
prefLabel
Lentiviral vectors containing ...... ession in hematopoietic cells.
@en
Lentiviral vectors containing ...... ting chromatin opening element
@nl
P2093
P2860
P50
P1433
P1476
Lentiviral vectors containing ...... ession in hematopoietic cells.
@en
P2093
Christine Kinnon
Fang Zhang
H Bobby Gaspar
Joanna Sinclair
Meera Ulaganathan
Michael Antoniou
Steven J Howe
Susannah I Thornhill
P2860
P304
P356
10.1182/BLOOD-2006-12-060814
P407
P577
2007-04-24T00:00:00Z