Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging - Wikidata - wikimedia - TriplyDB

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

http://www.wikidata.org/entity/Q25255924

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Selective gene silencing by viral delivery of short hairpin RNA An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling siRNA and RNAi optimization Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis In vivo bioluminescent imaging (BLI): noninvasive visualization and interrogation of biological processes in living animals Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain Attachment of cell-binding ligands to arginine-rich cell-penetrating peptides enables cytosolic translocation of complexed siRNA.Knocking down disease: a progress report on siRNA therapeutics Technologies for controlled, local delivery of siRNA Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34 Control of transient, resurgent, and persistent current by open-channel block by Na channel beta4 in cultured cerebellar granule neurons Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Cardiac Gene Expression Knockdown Using Small Inhibitory RNA-Loaded Microbubbles and Ultrasound.The dynamics and efficacy of antiviral RNA silencing: A model study.Modeling recursive RNA interference.Inhibitory efficacy of hypoxia-inducible factor 1alpha short hairpin RNA plasmid DNA-loaded poly (D, L-lactide-co-glycolide) nanoparticles on choroidal neovascularization in a laser-induced rat model.Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host.Advances in Systemic siRNA Delivery A rapid and sensitive method to detect siRNA-mediated mRNA cleavage in vivo using 5' RACE and a molecular beacon probe Nuclear-targeted siRNA delivery for long-term gene silencing.RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice Logic integration of mRNA signals by an RNAi-based molecular computer The roles of individual mammalian argonautes in RNA interference in vivo.Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line.siRNA knock-down of RANK signaling to control osteoclast-mediated bone resorption.2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles.Gene silencing by gold nanoshell-mediated delivery and laser-triggered release of antisense oligonucleotide and siRNA The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.A kinetic model for RNA-interference of focal adhesions.Increased tumor distribution and expression of histidine-rich plasmid polyplexes.RNAi therapeutics: principles, prospects and challenges.Estimate hidden dynamic profiles of siRNA effect on apoptosis.Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnover.Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing.Systemic delivery of small interfering RNA targeting the interleukin-2/15 receptor β chain prevents disease progression in experimental arthritis Non-viral nanoparticle delivers small interfering RNA to macrophages in vitro and in vivo.Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo.Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes.

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Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

http://www.wikidata.org/entity/Q25255924

description

2006 nî lūn-bûn

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P2860

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

The RNA silencing pathway: the bits and pieces that matter

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

How cells respond to interferons

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

siRNAs: applications in functional genomics and potential as therapeutics.

Unlocking the potential of the human genome with RNA interference.

Molecular and cellular barriers limiting the effectiveness of antisense oligonucleotides.

siRNA therapeutics: big potential from small RNAs.

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34

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1331994

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