Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain - Wikidata - wikimedia - TriplyDB

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

http://www.wikidata.org/entity/Q27317421

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NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface.Visualization of self-delivering hydrophobically modified siRNA cellular internalization.Gene Therapy: The View from NCATS.Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain The chemical evolution of oligonucleotide therapies of clinical utility.A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo.Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System.Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics.Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates.Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles.Efficient gene silencing in brain tumors with hydrophobically modified siRNAs.Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

http://www.wikidata.org/entity/Q27317421

description

2015 nî lūn-bûn

@nan

2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

@yue

name

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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type

label

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

@en

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

@nl

prefLabel

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

@ast

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

@en

Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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Molecular therapy. Nucleic acids

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Hydrophobically Modified siRNA ...... rimary Neurons and Mouse Brain

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Anastasia Khvorova

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Andrew H Coles

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Ellen Sapp

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Emily Johnson

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Emily Sottosanti

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Jasmin Abraham

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Julia F Alterman

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Kathryn Chase

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Lauren M Hall

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Maire F Osborn

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P2860

Oligonucleotide therapeutic approaches for Huntington disease

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

The promises and pitfalls of RNA-interference-based therapeutics

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

Asymmetry in the assembly of the RNAi enzyme complex

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Functional siRNAs and miRNAs exhibit strand bias

Current prospects for RNA interference-based therapies

NeuN, a neuronal specific nuclear protein in vertebrates

Silencing disease genes in the laboratory and the clinic

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scholarly article

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10.1038/MTNA.2015.38

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