Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release
about
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alphaAbnormal development of the neuromuscular junction in Nedd4-deficient miceRIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapseThe active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neuronsThe presynaptic active zoneRIM genes differentially contribute to organizing presynaptic release sitesNeurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortexRegion-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypesRIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneRIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophreniaPiccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosisRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionRIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learningCrystal structure of the RIM1alpha C2B domain at 1.7 A resolutionRIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functionsFunctions of Rab Proteins at Presynaptic SitesRab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zonesProtein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosisDifferential expression of liprin-α family proteins in the brain suggests functional diversificationMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexRab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channelsCryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tetheringIdentification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum.RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactionsRim1 modulates direct G-protein regulation of Ca(v)2.2 channels.Molecular underpinnings of synaptic vesicle pool heterogeneity.Spatio-temporal regulation of circular RNA expression during porcine embryonic brain developmentRIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.Fife, a Drosophila Piccolo-RIM homolog, promotes active zone organization and neurotransmitter releaseHypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle.The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses.cAMP/PKA signaling and RIM1alpha mediate presynaptic LTP in the lateral amygdala.CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampusMolecular mechanism of active zone organization at vertebrate neuromuscular junctions.Nicotinamide adenine dinucleotide-dependent binding of the neuronal Ca2+ sensor protein GCAP2 to photoreceptor synaptic ribbons.Association between regulating synaptic membrane exocytosis 2 gene polymorphisms and degenerative lumbar scoliosis.RIM proteins and their role in synapse function.Pushing synaptic vesicles over the RIM.
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P2860
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Redundant functions of RIM1alp ...... gered neurotransmitter release
@ast
Redundant functions of RIM1alp ...... gered neurotransmitter release
@en
Redundant functions of RIM1alp ...... gered neurotransmitter release
@nl
type
label
Redundant functions of RIM1alp ...... gered neurotransmitter release
@ast
Redundant functions of RIM1alp ...... gered neurotransmitter release
@en
Redundant functions of RIM1alp ...... gered neurotransmitter release
@nl
prefLabel
Redundant functions of RIM1alp ...... gered neurotransmitter release
@ast
Redundant functions of RIM1alp ...... gered neurotransmitter release
@en
Redundant functions of RIM1alp ...... gered neurotransmitter release
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Redundant functions of RIM1alp ...... gered neurotransmitter release
@en
P2093
Daniel Padgett
Frank Schmitz
Nicole Feldmann
Pascal S Kaeser
Robert E Hammer
Susanne Schoch
Tobias Mittelstaedt
Weichun Lin
Weiping Han
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7601425
P407
P577
2006-12-13T00:00:00Z