A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
about
Differential roles for snapin and synaptotagmin in the synaptic vesicle cycleRIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapseNeurotransmitter release: the last millisecond in the life of a synaptic vesicleThe presynaptic active zoneRIM determines Ca²+ channel density and vesicle docking at the presynaptic active zoneStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosisMunc18-1 binding to the neuronal SNARE complex controls synaptic vesicle primingRIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interactionCrystal structure of the RIM1alpha C2B domain at 1.7 A resolutionRIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functionsRedundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter releaseStructural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switchSumoylation in Synaptic Function and DysfunctionMolecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active ZoneFunctions of Rab Proteins at Presynaptic SitesThe dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteinsStructures and mechanisms of vesicle coat components and multisubunit tethering complexesRab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zonesThe Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering FactorsProtein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosisConical electron tomography of a chemical synapse: polyhedral cages dock vesicles to the active zoneMolecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretionRab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3Munc13-1 is required for presynaptic long-term potentiationMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexSuperpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength.Distinct actions of Rab3 and Rab27 GTPases on late stages of exocytosis of insulin.Characterization of Munc13-1 and insulin secretion during pancreatic development in rats.Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography.Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endingsHeterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactionsAt the junction of SNARE and SM protein function.Involvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.Calcium regulates vesicle replenishment at the cone ribbon synapse.Studying synaptic efficiency by post-hoc immunolabelling.Rab3a is critical for trapping alpha-MSH granules in the high Ca²⁺-affinity pool by preventing constitutive exocytosis.
P2860
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P2860
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@ast
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@en
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@nl
type
label
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@ast
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@en
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@nl
prefLabel
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@ast
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@en
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@nl
P2093
P2860
P3181
P356
P1433
P1476
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
@en
P2093
Irina Dulubova
Iryna Huryeva
Ralf Schneggenburger
Xuelin Lou
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600753
P407
P577
2005-08-17T00:00:00Z