about
Processing ribonucleotides incorporated during eukaryotic DNA replication.Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybridsStrong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeDynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active PromotersFunctions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase IThe monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences.Replicating Large Genomes: Divide and Conquer.Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.Putative RNA-Directed Adaptive Mutations in Cancer Evolution.Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybridsR-loop: an emerging regulator of chromatin dynamics.R Loops and Links to Human Disease.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.Nascent Connections: R-Loops and Chromatin Patterning.Conflict Resolution in the Genome: How Transcription and Replication Make It Work.The Role of Replication-Associated Repair Factors on R-LoopsClose encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.Ddx19 links mRNA nuclear export with progression of transcription and replication and suppresses genomic instability upon DNA damage in proliferating cells.Multiomic Analysis of the UV-Induced DNA Damage Response.Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage.Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity.Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin.RNase H As Gene Modifier, Driver of Evolution and Antiviral Defense.Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic diseaseCytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.The multidimensional mechanisms of long noncoding RNA function.PRPF8 is important for BRCA1-mediated homologous recombination.Genome integrity and disease prevention in the nervous system.Aquarius is required for proper CtIP expression and homologous recombination repair.The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage.Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response.Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops.Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts.DNA-RNA hybrids: the risks of DNA breakage during transcription.The curious case of APOBEC3 activation by cancer-associated human papillomaviruses.BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Breaking bad: R-loops and genome integrity
@ast
Breaking bad: R-loops and genome integrity
@en
Breaking bad: R-loops and genome integrity
@nl
type
label
Breaking bad: R-loops and genome integrity
@ast
Breaking bad: R-loops and genome integrity
@en
Breaking bad: R-loops and genome integrity
@nl
prefLabel
Breaking bad: R-loops and genome integrity
@ast
Breaking bad: R-loops and genome integrity
@en
Breaking bad: R-loops and genome integrity
@nl
P2860
P3181
P1476
Breaking bad: R-loops and genome integrity
@en
P2093
Julie Sollier
Karlene A. Cimprich
P2860
P304
P3181
P356
10.1016/J.TCB.2015.05.003
P407
P577
2015-09-01T00:00:00Z