The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
about
AID and APOBECs span the gap between innate and adaptive immunityThe histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationSolubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminaseA SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damageMutations, kataegis and translocations in B cells: understanding AID promiscuous activityEpigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseEpigenetic Codes Programing Class Switch RecombinationFail-safe transcription termination: Because one is never enoughThe 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human DiseaseThreading the barrel of the RNA exosomeRegulation of Aicda expression and AID activityBreaking bad: R-loops and genome integrityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationIgH chain class switch recombination: mechanism and regulationAID targeting is dependent on RNA polymerase II pausing.R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.RNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeTGF-β triggers HBV cccDNA degradation through AID-dependent deaminationConvergent transcription at intragenic super-enhancers targets AID-initiated genomic instabilityAID targeting: old mysteries and new challengesGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseATAD5 deficiency decreases B cell division and Igh recombinationAnalysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityProximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humansBinding of AID to DNA does not correlate with mutator activity.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionB cell TLRs and induction of immunoglobulin class-switch DNA recombination.Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitnessRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation.Negative supercoiling creates single-stranded patches of DNA that are substrates for AID-mediated mutagenesis.Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombinationSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondriaAssociation between targeted somatic mutation (TSM) signatures and HGS-OvCa progressionRPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycleThe AID-induced DNA damage response in chromatin.
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The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates
description
2011 nî lūn-bûn
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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
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2011年論文
@zh-mo
2011年論文
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2011年论文
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The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@ast
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en-gb
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@nl
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label
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@ast
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en-gb
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@nl
prefLabel
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@ast
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en-gb
The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@nl
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The RNA exosome targets the AI ...... nscribed duplex DNA substrates
@en
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Caitlyn R Wasserman
Celia Keim
Christopher D Lima
Darienne Myers
Duane R Wesemann
Evangelos Pefanis
Fei-Long Meng
Frederick W Alt
Haiteng Deng
Jennifer Eccleston
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10.1016/J.CELL.2011.01.001
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2011-02-04T00:00:00Z