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Pancreatic cancer stem cells: emerging target for designing novel therapy

Pancreatic cancer stem cells: emerging target for designing novel therapy

http://www.wikidata.org/entity/Q26863365

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Molecular therapeutics in pancreas cancer Increased Oxidative Stress as a Selective Anticancer Therapy Targeting CSCs in tumor microenvironment: the potential role of ROS-associated miRNAs in tumor aggressiveness The role of cancer stem cells and miRNAs in defining the complexities of brain metastasis Gastric cancer stem cells: a novel therapeutic target p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal Stem cells' guided gene therapy of cancer: New frontier in personalized and targeted therapy.PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma.Inflammation and Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma: Fighting Against Multiple Opponents Cancer stem cells: involvement in pancreatic cancer pathogenesis and perspectives on cancer therapeutics.Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.Transcriptional silencing of ETS-1 abrogates epithelial-mesenchymal transition resulting in reduced motility of pancreatic cancer cells Embryonic stem cell factors and pancreatic cancer JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells.Long noncoding RNA MALAT-1 enhances stem cell-like phenotypes in pancreatic cancer cells DKK3 blocked translocation of β-catenin/EMT induced by hypoxia and improved gemcitabine therapeutic effect in pancreatic cancer Bxpc-3 cell.Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells Bufalin suppresses cancer stem-like cells in gemcitabine-resistant pancreatic cancer cells via Hedgehog signaling.DEspR roles in tumor vasculo-angiogenesis, invasiveness, CSC-survival and anoikis resistance: a 'common receptor coordinator' paradigm.Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC)The roles of FOXM1 in pancreatic stem cells and carcinogenesis Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer.Role of Hippo signaling in cancer stem cells.Role of epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma: is tumor budding the missing link?Involvement of epithelial to mesenchymal transition in the development of pancreatic ductal adenocarcinoma.Role of Krüppel-like factors in cancer stem cells.Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells.Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.Polymeric Micelles of PEG-PLA Copolymer as a Carrier for Salinomycin Against Gemcitabine-Resistant Pancreatic Cancer.Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1.Pim-3 Regulates Stemness of Pancreatic Cancer Cells via Activating STAT3 Signaling Pathway.Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs).c-Met in pancreatic cancer stem cells: therapeutic implications.Combinatorial effects of an epigenetic inhibitor and ionizing radiation contribute to targeted elimination of pancreatic cancer stem cell.Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer.SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine.

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Pancreatic cancer stem cells: emerging target for designing novel therapy

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Pancreatic cancer stem cells: emerging target for designing novel therapy

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Pancreatic cancer stem cells: emerging target for designing novel therapy

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Pancreatic cancer stem cells: emerging target for designing novel therapy

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Pancreatic cancer stem cells: emerging target for designing novel therapy

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Aamir Ahmad

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Bin Bao

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Dejuan Kong

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Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.

Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

A stochastic model for cancer stem cell origin in metastatic colon cancer

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths

Identification of selective inhibitors of cancer stem cells by high-throughput screening

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