Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal - Wikidata - wikimedia - TriplyDB

Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal

Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal

http://www.wikidata.org/entity/Q28484138

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Novel therapeutic targets for pancreatic cancer Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Hedgehog Signaling in the Maintenance of Cancer Stem Cells Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition Sustained proliferation in cancer: Mechanisms and novel therapeutic targets Expression and Clinical Significance of Cancer Stem Cell Markers CD24, CD44, and CD133 in Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy: Targeting Cellular Signaling, MicroRNAs, and Epigenome.Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.Embelin suppresses growth of human pancreatic cancer xenografts, and pancreatic cancer cells isolated from KrasG12D mice by inhibiting Akt and Sonic hedgehog pathways.New insights into pancreatic cancer stem cells.A concise review on the current understanding of pancreatic cancer stem cells Cancer stem cells and chemoresistance: The smartest survives the raid Targeting sonic hedgehog signaling by compounds and derivatives from natural products Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway.Kinetics of sulforaphane in mice after consumption of sulforaphane-enriched broccoli sprout preparation.The roles of FOXM1 in pancreatic stem cells and carcinogenesis Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.Stem cell-directed therapies in pancreatic cancer.Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer.Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells.Protein kinases and associated pathways in pluripotent state and lineage differentiation.Role of microRNAs in maintaining cancer stem cells.Food systems approach to cancer prevention.Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells.Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer.Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells.Polyphenols delivery by polymeric materials: challenges in cancer treatment.Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells.NOTCH1 Activation Depletes the Pool of Side Population Stem Cells in ATL.Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling.

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Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal

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Sonic hedgehog signaling inhib ...... cancer stem cell self-renewal

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Dara Nall Watkins

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Junsheng Fu

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Mariana Rodova

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Rakesh K Srivastava

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Sharmila Shankar

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P2860

Pancreatic cancer stem cells: emerging target for designing novel therapy

Cancer statistics, 2010

Stem cells, cancer, and cancer stem cells

Nanog: a new recruit to the embryonic stem cell orchestra

Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition

Patched1 regulates hedgehog signaling at the primary cilium

Hedgehog: functions and mechanisms

Pancreatic cancer: pathobiology, treatment options, and drug delivery.

Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells.

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.

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