Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention - Wikidata - wikimedia - TriplyDB

Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention

Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention

http://www.wikidata.org/entity/Q26994739

about

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia Synthesis of lysine methyltransferase inhibitors EZH2 in Bladder Cancer, a Promising Therapeutic Target Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects Genetic alterations of histone lysine methyltransferases and their significance in breast cancer An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer Accelerating trypsin digestion: the immobilized enzyme reactor.Targeting chromatin to improve radiation response.Targeting of cancer stem cells by inhibitors of DNA and histone methylation.Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3.Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents.The promise of epigenomic therapeutics in pancreatic cancer CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies.Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.Analysis of Pelagia noctiluca proteome Reveals a Red Fluorescent Protein, a Zinc Metalloproteinase and a Peroxiredoxin.Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression.

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Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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Histone lysine-specific methyl ...... cancer therapy and prevention

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Histone lysine-specific methyl ...... cancer therapy and prevention

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Current Cancer Drug Targets

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Histone lysine-specific methyl ...... cancer therapy and prevention

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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Repression of p53 activity by Smyd2-mediated methylation

Identification of the MLL2 complex as a coactivator for estrogen receptor alpha

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation

The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

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