Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁)
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The search for novel analgesics: targets and mechanismsChemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsN-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.Identification of Nitazoxanide as a Group I Metabotropic Glutamate Receptor Negative Modulator for the Treatment of Neuropathic Pain: An In Silico Drug Repositioning Study.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryPractical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksAllosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Re-exploration of the mGlu₁ PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR.Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild TypeOctahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.Preclinical anaylses of [18F]cEFQ as a PET tracer for imaging metabotropic glutamate receptor type 1 (mGluR1).
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Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁)
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@ast
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
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Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
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type
label
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@ast
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@en
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@nl
prefLabel
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@ast
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@en
Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@nl
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Recent advances in the medicin ...... c glutamate receptor 1 (mGlu₁)
@en
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Dafydd R. Owen
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10.1021/CN2000124
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2011-08-17T00:00:00Z