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SLC transporters as therapeutic targets: emerging opportunities

SLC transporters as therapeutic targets: emerging opportunities

http://www.wikidata.org/entity/Q27014726

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Biomolecular Network-Based Synergistic Drug Combination Discovery Size distribution of function-based human gene sets and the split-merge model A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies.A critical role of solute carrier 22a14 in sperm motility and male fertility in mice Role of Transporters in Central Nervous System Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke Importance of Drug Pharmacokinetics at the Site of Action Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake.Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability.K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse Fibroblasts Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.Establishment and Dysfunction of the Blood-Brain Barrier.Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4 The gut reaction to traumatic brain injury.SLC Transporters: Structure, Function, and Drug Discovery.Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation.Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas.RNA-seq reveals conservation of function among the yolk sacs of human, mouse, and chicken.Pharmacogenetics of anthracyclines.Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease.Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant?Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.Harnessing Solute Carrier Transporters for Precision Oncology.Efflux proteins at the blood-brain barrier: review and bioinformatics analysis.Pre-formulation and systematic evaluation of amino acid assisted permeability of insulin across in vitro buccal cell layers.Atomistic modeling of alternating access of a mitochondrial ADP/ATP membrane transporter with molecular simulations.Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug.Molecular dissection of the valproic acid effects on glioma cells.Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression.Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition ρ⁰ Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids.Putative transmembrane transporter modulates higher-level aggression in Drosophila.A Numbering System for MFS Transporter Proteins.Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice.Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination.Low SLC29A1 expression is associated with poor prognosis in patients with hepatocellular carcinoma.

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SLC transporters as therapeutic targets: emerging opportunities

http://www.wikidata.org/entity/Q27014726

description

2015 nî lūn-bûn

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2015 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի օգոստոսին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年论文

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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SLC transporters as therapeutic targets: emerging opportunities

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Nature Reviews Drug Discovery

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SLC transporters as therapeutic targets: emerging opportunities

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Kathleen M Giacomini

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Lawrence Lin

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Richard B Kim

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P2860

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)

Genetic implication of a novel thiamine transporter in human hypertension.

Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

Exome sequencing identifies the cause of a mendelian disorder

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

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10.1038/NRD4626

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