LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake - Wikidata - wikimedia - TriplyDB

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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X-ray structure of dopamine transporter elucidates antidepressant mechanism The neuronal transporter gene SLC6A15 confers risk to major depression The binding sites for cocaine and dopamine in the dopamine transporter overlap Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition Monoamine transporters: insights from molecular dynamics simulations Insights to ligand binding to the monoamine transporters-from homology modeling to LeuBAT and dDAT Designing modulators of monoamine transporters using virtual screening techniques Physicochemical Properties of Ion Pairs of Biological Macromolecules Visualizing functional motions of membrane transporters with molecular dynamics simulations Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter Nonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substrates SLC transporters as therapeutic targets: emerging opportunities A steered molecular dynamics study of binding and translocation processes in the GABA transporter A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologue Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter A competitive inhibitor traps LeuT in an open-to-out conformation.Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation The mechanism of sodium and substrate release from the binding pocket of vSGLT Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines Insights into transport mechanism from LeuT engineered to transport tryptophan X-ray structures of LeuT in substrate-free outward-open and apo inward-open states Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context Structural basis for action by diverse antidepressants on biogenic amine transporters The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations Mapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular Dynamics Directed evolution reveals hidden properties of VMAT, a neurotransmitter transporter Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles Novel molecular targets of dezocine and their clinical implications Conformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Structures of membrane proteins.A gate-free pathway for substrate release from the inward-facing state of the Na⁺-galactose transporter Substrate binding and formation of an occluded state in the leucine transporter.4-(4-(dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter.Insights from molecular dynamics: the binding site of cocaine in the dopamine transporter and permeation pathways of substrates in the leucine and dopamine transporters.Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood.Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling.

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

http://www.wikidata.org/entity/Q24598921

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2007 nî lūn-bûn

@nan

2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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type

label

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

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Christopher J Law

http://www.w3.org/2001/XMLSchema#string

Da-Neng Wang

http://www.w3.org/2001/XMLSchema#string

Juan Zhen

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Maarten E A Reith

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Nathan K Karpowich

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Regina M Goetz

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Zheng Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Plasma membrane monoamine transporters: structure, regulation and function

Neurotransmitter transporters and their impact on the development of psychopharmacology

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

Drug discovery: a historical perspective

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

Cation-pi interactions in structural biology

The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines.

How do antidepressants work? Prospects for genetic analysis of drug mechanisms.

Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.

Families of transmembrane transporters selective for amino acids and their derivatives.

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