Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints - Wikidata - wikimedia - TriplyDB

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

http://www.wikidata.org/entity/Q27021652

about

Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain Conformational diversity in contryphans from Conus venom: cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis Hydrocarbon-stapled peptides: principles, practice, and progress A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake 4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries.Targeting YAP/TAZ-TEAD protein-protein interactions using fragment-based and computational modeling approaches.Large ring-forming alkylations provide facile access to composite macrocycles Modeling kinetics and equilibrium of membranes with fields: milestoning analysis and implication to permeation.Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides.Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.Comprehensive analysis of loops at protein-protein interfaces for macrocycle design.Cone snail venomics: from novel biology to novel therapeutics.cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides? .Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators.Conformational Restriction of Peptides Using Dithiol Bis-Alkylation Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display.Bicyclic Peptides as Next-Generation Therapeutics.Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.Degradation of Akt using protein-catalyzed capture agents.Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids Strategies for the development of conotoxins as new therapeutic leads.Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazin-4-olate Solvates.Targeted delivery of ubiquitin-conjugated BH3 peptide-based Mcl-1 inhibitors into cancer cells Peptides for immunological purposes: design, strategies and applications.Getting across the cell membrane: an overview for small molecules, peptides, and proteins.Strategies to stabilize cell penetrating peptides for in vivo applications.Toward accurately modeling N-methylated cyclic peptides.Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.Genetically encoding new bioreactivity.Peptidomimetic therapeutics: scientific approaches and opportunities.Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.Peptide/protein stapling and unstapling: introduction of s-tetrazine, photochemical release, and regeneration of the peptide/protein.Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge.Tetrahydrofuran amino acid-containing gramicidin S analogues with improved biological profiles.

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Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

http://www.wikidata.org/entity/Q27021652

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Getting in shape: controlling ...... ing conformational constraints

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Getting in shape: controlling ...... ing conformational constraints

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Getting in shape: controlling ...... ing conformational constraints

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Getting in shape: controlling ...... ing conformational constraints

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Getting in shape: controlling ...... ing conformational constraints

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Getting in shape: controlling ...... ing conformational constraints

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ACS Chemical Biology

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Getting in shape: controlling ...... ing conformational constraints

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Jonathan E Bock

http://www.w3.org/2001/XMLSchema#string

Joshua A Kritzer

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P2860

A stapled BID BH3 helix directly binds and activates BAX

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein

Direct inhibition of the NOTCH transcription factor complex

All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.

Gene family encoding the major toxins of lethal Amanita mushrooms

NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

Design and structure of stapled peptides binding to estrogen receptors

Bicyclic peptide inhibitor reveals large contact interface with a protease target

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488-499

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scholarly article

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1045482

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10.1021/CB300515U

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3

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8

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Jason Gavenonis

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2012-11-30T00:00:00Z

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23170954

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4847942

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