Hydrocarbon-stapled peptides: principles, practice, and progress - Wikidata - wikimedia - TriplyDB

Hydrocarbon-stapled peptides: principles, practice, and progress

Hydrocarbon-stapled peptides: principles, practice, and progress

http://www.wikidata.org/entity/Q28542025

about

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units Synthetic Peptides as Protein Mimics Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne Metathesis Motif mediated protein-protein interactions as drug targets The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.A bicyclic peptide scaffold promotes phosphotyrosine mimicry and cellular uptake Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders.Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics.Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity.Cullin3-BTB interface: a novel target for stapled peptides High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists Discovering functional, non-proteinogenic amino acid containing, peptides using genetic code reprogramming.GLUE that sticks to HIV: a helix-grafted GLUE protein that selectively binds the HIV gp41 N-terminal helical region.Protein-Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals?Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1 Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.Stapled Peptides by Late-Stage C(sp3 )-H Activation.A coiled-coil mimetic intercepts BCR-ABL1 dimerization in native and kinase-mutant chronic myeloid leukemia A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.An optimal hydrogen-bond surrogate for α-helices.Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery.Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.Degradation of Akt using protein-catalyzed capture agents.Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.Serum Stability and Affinity Optimization of an M2 Macrophage-Targeting Peptide (M2pep).hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.

P2860

Q26744973-C9748E71-8DCE-4403-AB28-9B37CC478124 Q26770255-72324A50-3A1C-4570-A28C-A5FBF15A516E Q27703615-138A067D-7381-40FA-8F6C-52236C01C5FC Q27728007-A674D0FC-096E-4605-8E60-FCD6D26AE626 Q28079554-FA722796-6A6C-48D8-A640-4AE020E7F6E7 Q28547465-B766F6A4-DDD1-4C42-A188-7E3CD921354A Q30378305-FEEE5666-D7D4-499B-820C-BEF2C24D0623 Q30855871-87844EE2-7E36-4F61-943E-50EF2175068D Q30872676-45D45066-B103-4F9B-A768-CDD900258C29 Q33606810-0F66CD8B-16EF-4846-9D99-D669CFE783D1 Q33687329-8C236145-11F9-4570-B5E0-8AA0A684F0E0 Q33899470-F08F2EDD-27FF-4B75-BAE1-B4547D6ACA14 Q34245561-DBC02490-64A9-4015-9CAA-7D928AF22B7D Q34481459-8413B4C3-EA26-491F-9C65-F89D5C177B2E Q35013460-B2E6B39A-6869-4C07-ABFB-C5EB54FD3505 Q35089991-92015817-803B-4142-A216-170D11F6A499 Q35582339-7E3A83CF-EA14-42F3-A136-E224D55FF678 Q35596110-800D8D7B-595E-46D1-9572-5684B1958103 Q35634594-7F2E4381-EA76-4830-A373-591D7546ABE6 Q35747679-FFFC1136-04F5-4014-987C-EDFEA522CA25 Q35751518-94BE6F4B-6EB4-4F7F-A3D2-CB460D40A207 Q35808644-6FA1C381-D5F9-4C69-903E-42510231375B Q35837170-162B4CAE-50C0-41B7-9189-D033492187C5 Q35863269-BA24C61E-534E-46BC-84B3-57F12F9104B5 Q35876252-15197E51-64D9-427F-B0CD-73AFBF61FC6F Q35981250-918DCA80-0BF6-4502-A0C1-EC7421698C29 Q36108890-A8545A99-516A-4A59-AF76-1171D99C798C Q36137060-57E2F70C-2D45-426C-807C-B62A930B3E5A Q36207585-7810794E-94B9-4DF5-B83A-3D27CF4DBAC2 Q36210636-D1884124-FC80-40F7-8FDC-FD58D350BFE5 Q36339600-EA189CA1-7298-4F44-B981-A6B37694FB4E Q36813449-D1FB4D18-F838-4423-AF7A-826F1AD9981B Q36821353-83836757-9929-47A7-A774-CB622D7BD791 Q36844176-1C63B8EB-B271-4FB6-AD7E-109E40156CC7 Q36943802-D19B126C-D8DB-4C5F-8311-AD2F4B45FAD7 Q36964946-390DB610-4D6B-4B6B-8213-2AD1926675A2 Q37045947-620FC342-7057-4CF1-9BDE-B5F5D5B565BF Q37657934-AB8D3D82-B393-4F9E-9782-6EE91E14E0E2 Q37712074-D57DBD9B-5B0E-4751-AB7B-D53826D6C95D Q38387363-0638CA76-DDCE-4B9B-BBA6-421CD1E5CBC3

P2860

Hydrocarbon-stapled peptides: principles, practice, and progress

http://www.wikidata.org/entity/Q28542025

description

2014 nî lūn-bûn

@nan

2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Hydrocarbon-stapled peptides: principles, practice, and progress

@ast

Hydrocarbon-stapled peptides: principles, practice, and progress

@en

Hydrocarbon-stapled peptides: principles, practice, and progress

@nl

type

label

Hydrocarbon-stapled peptides: principles, practice, and progress

@ast

Hydrocarbon-stapled peptides: principles, practice, and progress

@en

Hydrocarbon-stapled peptides: principles, practice, and progress

@nl

prefLabel

Hydrocarbon-stapled peptides: principles, practice, and progress

@ast

Hydrocarbon-stapled peptides: principles, practice, and progress

@en

Hydrocarbon-stapled peptides: principles, practice, and progress

@nl

P1433

Q28542025-764B07A6-DC17-40B6-9BBE-8F201E5BE931

P1476

Q28542025-767D0155-036E-447A-8654-5830920B596D

P2093

Q28542025-94A1ABD2-A5E0-4F6E-8F30-FF009A779187

Q28542025-C9342682-20FE-46D7-B5A2-D26D320A10CC

P2860

Q28542025-07365E21-C0E6-4A36-916A-CEFEB0E3A1F5

Q28542025-13E3FEA8-2AB6-40BF-8669-36360A322B85

Q28542025-13FAB971-487E-42AF-B5D2-03763035615C

Q28542025-17EF9CDC-9ECC-4F94-879D-46086EBFFA62

Q28542025-1D9EF90B-7F6D-4896-8605-9F66E7923F11

Q28542025-1E00A927-97EA-46C6-BE20-1A9AAD15CE25

Q28542025-22A1551D-26E2-41DC-AE97-1EC065A81D6F

Q28542025-29FD67FA-EDD8-4AD8-A91C-7E26A1B6E5B8

Q28542025-2FA71E20-482E-4E36-84B5-B7DF9337DEC5

Q28542025-3124E3C9-030E-4C6B-A146-8A2E1E7E5589

P304

Q28542025-511F18F9-1794-4D7E-B85C-B3CF8C5AD196

P31

Q28542025-4FFE8414-452A-4874-9CC4-71B17A5C070E

Q28542025-651E1928-E68A-4218-9316-CEFED1FB3118

P3181

Q28542025-3825A56D-DF17-4A78-A737-0AD30C191CCF

P356

Q28542025-8B7F3638-F4FF-4DBD-9EE5-CFCA93B62E52

P407

Q28542025-3CBCA687-176E-4076-B9D1-125D51732F10

P433

Q28542025-A23EB76E-086E-4304-8B66-2AA776310E34

P478

Q28542025-20C72304-05D5-446C-874F-86D8D4A617D7

P577

Q28542025-EA048919-2A90-4029-B69E-61020807808B

P5875

Q28542025-45930F9C-C201-49FB-BA78-0D6022836761

P698

Q28542025-866E3A8C-E47C-41E0-B4B3-C42BD9D60553

P921

Q28542025-02CA50B3-376E-42EE-B276-39992D5543E8

Q28542025-235BC755-71C5-4807-8042-F2F7F3184004

Q28542025-5BAB86DD-2F5D-4C07-84D8-91B01A4D8789

P932

Q28542025-F4207D00-3769-4301-B325-B566FE1F3096

P3181

P356

P1433

Journal of Medicinal Chemistry

P1476

Hydrocarbon-stapled peptides: principles, practice, and progress

@en

P2093

Gregory H Bird

http://www.w3.org/2001/XMLSchema#string

Loren D Walensky

http://www.w3.org/2001/XMLSchema#string

P2860

A stapled BID BH3 helix directly binds and activates BAX

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

Direct inhibition of the NOTCH transcription factor complex

Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations

Synthesis and NMR solution structure of an α-helical hairpin stapled with two disulfide bridges

Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid

BAX activation is initiated at a novel interaction site

P304

6275-88

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

764980

http://www.w3.org/2001/XMLSchema#string

P356

10.1021/JM4011675

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

57

http://www.w3.org/2001/XMLSchema#string

P577

2014-08-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

260606717

http://www.w3.org/2001/XMLSchema#string

P698

24601557

http://www.w3.org/2001/XMLSchema#string

P921

P932

4136684

http://www.w3.org/2001/XMLSchema#string