Genetic variants in the complement system predisposing to age-related macular degeneration: a review - Wikidata - wikimedia - TriplyDB

Genetic variants in the complement system predisposing to age-related macular degeneration: a review

Genetic variants in the complement system predisposing to age-related macular degeneration: a review

http://www.wikidata.org/entity/Q27021836

about

Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases Complement regulator CD46: genetic variants and disease associations Complement regulators in human disease: lessons from modern genetics.DNA Sequence Analysis in Clinical Medicine, Proceeding Cautiously.Age-related macular degeneration: insights into inflammatory genes.Closing the gap between knowledge and clinical application: challenges for genomic translation Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention.Potential role of lampalizumab for treatment of geographic atrophy.Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization.Complement Dysregulation and Disease: Insights from Contemporary Genetics.Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration.Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention.Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9 Age-related macular degeneration: genome-wide association studies to translation.Increased choroidal mast cells and their degranulation in age-related macular degeneration Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.The relationship of circulating proteins in early pregnancy with preterm birth.Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae.From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET.Complement factor H in host defense and immune evasion.Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery.Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study.A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.Enhanced Detection of Sub-Retinal Pigment Epithelial Cell Layer Deposits in Human and Murine Tissue: Imaging Zinc as a Biomarker for Age-Related Macular Degeneration (An American Ophthalmological Society Thesis).Retinal Pigment Epithelial Cells Mitigate the Effects of Complement Attack by Endocytosis of C5b-9.Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration.Bruch's Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration.Bruch’s Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration.Assessing individual risk for AMD with genetic counseling, family history, and genetic testing.C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation.Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.The eye as a complement dysregulation hotspot.Lipid radicals cause light-induced retinal degeneration.Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants.

P2860

Q27007111-4DE25610-2189-4173-B6D9-E0151AB3554D Q28263110-8D4B10A6-8F5E-45EA-94AF-F46AF227DA24 Q33419261-25029C82-6560-4A0F-9154-3C0937DE6113 Q33627712-35BBF246-7B07-4EBD-9E43-1342FC23617C Q34588628-ECD0589E-1223-41C1-B654-10F8E2D0F38B Q35126221-76273549-E974-438B-A998-6E65F730CA39 Q35236103-0F2CA62A-707B-4A90-B81C-B9DDA3F0FFC8 Q35746909-EAE7C11C-BD73-44EB-A48C-5F11A7970471 Q35846008-3E024438-F023-4A21-8689-7E27C5D11043 Q36221928-9426FF33-FED4-482D-8228-E4C916B3D6AD Q36223020-EA062579-B9CD-49B5-AE8A-4D961A5ABFD7 Q36228563-3119378F-3C10-476B-ACBD-3DF60094D0BC Q36447625-7A6DC4BE-D68B-4512-99C3-04E0AFC45D71 Q36460034-44B6B3B8-37CD-4315-9E5F-46AEE8352E95 Q36666116-AE146F89-492C-4B67-8BEB-721690FF5D55 Q36773888-180E0A32-A24F-4FF1-A1D5-A01A35394019 Q37020593-0A0000A1-DE7B-4640-9F60-E59C9618E411 Q37371329-F20EF6B2-4959-4AC6-864F-E9001099062A Q37486145-AE37C666-ACCE-47D4-B436-7362AF489AEA Q38864097-63C5ED6B-0E71-4272-9E3A-E45B510BB4AE Q38879877-C7FA477F-80CE-4ADD-85D0-5D66E902E7F4 Q39024579-9BA8BF3C-1467-4EFF-8FBD-146F9D1878C6 Q39036058-ECFE3E52-6C81-420E-9B8F-7341274A142B Q39246952-8527894D-F70D-488F-9454-EFC2B1F9D6CB Q40050562-2BDD7049-6D7F-464F-AE9B-A0907E0EC658 Q42119687-310D5598-1EE0-4FE5-8D93-12D5EC00D472 Q42261791-B5442B58-1EC2-4DCD-BB0D-7EB8393BB77E Q42481764-A8FE08CA-5D9F-4752-BE40-956328093402 Q43162540-AA1852FB-5916-4911-BFA3-CF669DF140AD Q47221253-3F9B3B95-B53A-4797-B3A0-21B995CDCEBA Q47232126-C74FA1BE-C422-4084-AD1F-BD32C3591F2D Q47673838-21D36E2F-EA46-49DC-B9B7-B226E2497285 Q48157978-32C93C77-5712-49AB-927F-5531331A7EB0 Q48240873-4323CD3C-EA1E-48CE-B3E4-2900206645D0 Q48290530-826D79BA-E3A4-4458-8C83-DECECFE69D6C Q49994873-B0EFC7B6-20DF-453F-B4B4-D41B31D3A940 Q52659567-39D3FE85-EB2E-4B72-859B-6FB23567E75C Q54965254-48E4CEBA-03DF-4CEC-8D32-A55A2316F1C8

P2860

Genetic variants in the complement system predisposing to age-related macular degeneration: a review

http://www.wikidata.org/entity/Q27021836

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Genetic variants in the comple ...... macular degeneration: a review

@ast

Genetic variants in the comple ...... macular degeneration: a review

@en

Genetic variants in the comple ...... macular degeneration: a review

@nl

type

label

Genetic variants in the comple ...... macular degeneration: a review

@ast

Genetic variants in the comple ...... macular degeneration: a review

@en

Genetic variants in the comple ...... macular degeneration: a review

@nl

prefLabel

Genetic variants in the comple ...... macular degeneration: a review

@ast

Genetic variants in the comple ...... macular degeneration: a review

@en

Genetic variants in the comple ...... macular degeneration: a review

@nl

P1433

Q27021836-4ADD52F2-EDB6-4174-B3E3-4081DD4CC55B

P1476

Q27021836-EBB46410-CE7C-48E0-9943-D624EFF76641

P2093

Q27021836-0FF4F91E-1E9C-4F26-B8E4-AFD570FB14D1

Q27021836-24F6C539-AC32-4E09-BB21-DB9495671F7B

Q27021836-60B8F6B4-18A9-43F4-A1C7-EFE3DF1A1B3B

Q27021836-6B685E94-740D-4846-AB00-99FB31D84565

P2860

Q27021836-0705981A-83E6-43EC-97B9-AA94EB360C25

Q27021836-08FA4552-CFD8-49BB-960A-B9DAD8FE4457

Q27021836-0A12F656-232B-4291-8518-433437C54B37

Q27021836-0A773E6D-5416-4711-910B-E2A7BF645579

Q27021836-0BC8436B-2C71-4111-A2E9-022AC22E4683

Q27021836-19427FE3-F26B-4339-9344-CBF70BAA5452

Q27021836-287C6A2C-FA93-411F-A1A5-DEBCAF606D8B

Q27021836-29B7E833-FEBA-47CA-B0C3-EDF9A4AFDFE7

Q27021836-37D69825-6016-4EAD-BD59-DF90D2B94832

Q27021836-3BE4396E-CC65-4321-B63C-BDF76517F01F

P304

Q27021836-8CCCA6D3-1211-4ADF-AD79-7960AEF52986

P31

Q27021836-EA0ACC4F-ABFB-4845-A8C3-0318815060F2

P3181

Q27021836-D7CD09B7-01FA-4512-A4B5-11533B4B4D98

P356

Q27021836-D92EF33D-AD1E-4B27-9A26-E2F1571959E4

P407

Q27021836-7E441662-F96E-4569-82A7-D596599A43AF

P433

Q27021836-53FACECF-6625-4052-8B68-9D76DFDA993F

P478

Q27021836-04E51025-D895-41AF-B0F1-1D0CA3947731

P50

Q27021836-3258C08F-31E1-40D4-8B5D-85F4E0774D9A

Q27021836-BB889588-A9F2-4FF8-945E-4DB146220419

P577

Q27021836-AB76DEBB-D906-47A2-A5FC-4ACC0D7F95FF

P5875

Q27021836-BE88BFB6-73A8-4480-B428-8233134BC2DC

P698

Q27021836-CE174EA3-EF08-4396-B907-E552B44F87FD

P932

Q27021836-A7BCD88E-A4C6-49B1-891D-C3F507C0EB6C

P3181

P356

J.MOLIMM.2014.06.032

P1433

Molecular Immunology

P1476

Genetic variants in the comple ...... macular degeneration: a review

@en

P2093

Elizabeth C Schramm

http://www.w3.org/2001/XMLSchema#string

Johanna Seddon

http://www.w3.org/2001/XMLSchema#string

John P Atkinson

http://www.w3.org/2001/XMLSchema#string

Michael P Triebwasser

http://www.w3.org/2001/XMLSchema#string

P2860

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Complement factor H polymorphism in age-related macular degeneration

Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration

Variation near complement factor I is associated with risk of advanced AMD

Complement in age-related macular degeneration: a focus on function

Structure of complement fragment C3b-factor H and implications for host protection by complement regulators

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

Dimerization of complement factor H-related proteins modulates complement activation in vivo

P304

118-125

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1193544

http://www.w3.org/2001/XMLSchema#string

P356

10.1016/J.MOLIMM.2014.06.032

http://www.w3.org/2001/XMLSchema#string

P407

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

61

http://www.w3.org/2001/XMLSchema#string

P50

Soumya Raychaudhuri

P577

2014-07-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

263930751

http://www.w3.org/2001/XMLSchema#string

P698

25034031

http://www.w3.org/2001/XMLSchema#string

P932

4149817

http://www.w3.org/2001/XMLSchema#string