about
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized statePhotoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
L-685,458
@en
type
label
L-685,458
@en
altLabel
(1S,2R,4R)-{1-benzyl-4-[1-(1S) ...... carbamic acid tert-butyl ester
@en
(5S)-[tert-butoxycarbonylamino-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl]-L-Leu-L-Phe-NH2
@en
L-685458
@en
{(1S)-benzyl-(4R)-[1-((1S)-car ...... carbamic acid tert-butyl ester
@en
{1(S)-benzyl-4(R)-[1-(1(S)-car ...... carbamic acid tert-butyl ester
@en
prefLabel
L-685,458
@en
P592
P661
P662
P683
P1579
P2017
CC(C)C[C@@H](C(=O)N[C@@H](CC1= ...... CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O
P2067
P233
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C ...... CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O
P234
1S/C39H52N4O6/c1-26(2)21-33(37 ...... 48)/t30-,31+,32+,33+,34-/m1/s1
P235
MURCDOXDAHPNRQ-ZJKZPDEISA-N
P274
C₃₉H₅₂N₄O₆
P592
CHEMBL302004