Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
about
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complexGamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexMammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and NotchSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Gleevec inhibits beta-amyloid production but not Notch cleavageThe presenilinsStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsDiabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Modelsγ-Secretase inhibitors and modulators.Toward the structure of presenilin/γ-secretase and presenilin homologsGeneral anesthetics and β-amyloid proteinThree-dimensional structure of human γ-secretaseAPP processing in Alzheimer's diseaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsRegulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogeneThe Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsCompounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeuticsA nine-transmembrane domain topology for presenilin 1Assembly, trafficking and function of gamma-secretaseEvidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathwayPresenilin clinical mutations can affect gamma-secretase activity by different mechanismsSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseIdentification of an archaeal presenilin-like intramembrane proteasePresenilin 1 is required for maturation and cell surface accumulation of nicastrinModeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tauPresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membraneSpatial segregation of gamma-secretase and substrates in distinct membrane domains.Pathogenic PS1 phosphorylation at Ser367Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivoRecent trends in protein biochip technology.A new functional screening system for identification of regulators for the generation of amyloid beta-protein.Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".Identification of prostate specific membrane antigen (PSMA) as the target of monoclonal antibody 107-1A4 by proteinchip; array, surface-enhanced laser desorption/ionization (SELDI) technology.Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures.
P2860
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P2860
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@ast
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en-gb
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@nl
type
label
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@ast
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en-gb
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@nl
prefLabel
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@ast
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en-gb
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@nl
P2093
P2860
P3181
P356
P1476
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
@en
P2093
J A Shafer
J DiMuzio-Mower
M K Sardana
S J Gardell
P2860
P304
P3181
P356
10.1073/PNAS.110126897
P407
P577
2000-05-23T00:00:00Z