about
Structural basis of microtubule stabilization by laulimalide and peloruside ALaulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.Resistance to peloruside A and laulimalide: functional significance of acquired βI-tubulin mutations at sites important for drug-tubulin binding.Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells.βII-tubulin and βIII-tubulin mediate sensitivity to peloruside A and laulimalide, but not paclitaxel or vinblastine, in human ovarian carcinoma cells.Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A.Effects of the microtubule stabilizing agent peloruside A on the proteome of HL-60 cells.Microtubule-stabilizing agents delay the onset of EAE through inhibition of migration.Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation.Chemical genetic profiling of the microtubule-targeting agent peloruside A in budding yeast Saccharomyces cerevisiaePeloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activityDocking and molecular dynamics studies of the binding between Peloruside A and tubulin
P921
Q27689025-35FFC86C-A500-4212-B300-C3524633F59DQ34993896-1AF5439A-56BE-4C07-ADFC-F2B67D8E0123Q35600753-3F846676-CAA3-4C1A-B687-08B5E5C7849DQ39061864-361F14AF-47C1-4DEE-9B99-B378F9F9C25AQ39348373-72361E85-7EDB-4AFC-AF6D-313DDA9F2F75Q39425922-7FE84341-3C45-4524-9380-1625A5404A36Q39652507-E9F05F71-F31F-41D2-9710-3424A8C2A792Q39747031-B80C1A4C-5F41-43B7-BBE5-DFA3DC3D5392Q46438072-FD20D5AC-C38C-4481-8ED0-4B8AB72F4110Q48680605-2B104153-06FC-4344-9692-7D883F52A684Q59563708-67FB2BBC-3E24-4692-BE11-CF8F22A3E177Q74309175-D0158FA2-A0DF-46B3-BB2F-195A37BE1635Q86582829-56BA6BCE-7517-489F-B709-BD758885B4AB
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
peloruside A
@en
type
label
peloruside A
@en
altLabel
(-)-peloruside A
@en
prefLabel
peloruside A
@en
P661
P662
P683
P1579
P2017
CC[C@H](CO)/C=C(/C)\[C@H]1C[C@ ...... (C(=O)O1)O)OC)OC)O)O)(C)C)O)OC
P2067
P233
CCC(CO)C=C(C)C1CC(CC(C(C2(C(C(CC(O2)CC(C(C(=O)O1)O)OC)OC)O)O)(C)C)O)OC
P234
1S/C27H48O11/c1-8-16(14-28)9-1 ...... ,20-,21-,22+,23+,24-,27+/m0/s1
P235
NETARJWZTMGMRM-JRTPPQMASA-N