Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
about
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaThe Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome.Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in miceHypothalamic Dysfunction and Multiple Sclerosis: Implications for Fatigue and Weight DysregulationSuvorexant for the treatment of insomnia.The Neurobiology of Sleep and WakefulnessHomeostatic sleep pressure is the primary factor for activation of cortical nNOS/NK1 neuronsThe duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice.Hypocretin receptor 1 blockade preferentially reduces high effort responding for cocaine without promoting sleep.Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsyTranslational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.Intrathecal Intermittent Orexin-A Causes Sympathetic Long-Term Facilitation and Sensitizes the Peripheral Chemoreceptor Response to Hypoxia in RatsOrexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preferenceA role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity.Orexin receptor antagonists as therapeutic agents for insomniaOrexin, orexin receptor antagonists and central cardiovascular control.The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in ratsOrexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status.Sites of action of sleep and wake drugs: insights from model organisms.Differential roles of orexin receptors in the regulation of sleep/wakefulness.Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?Small-molecule antagonists of the orexin receptors.Role of orexin in respiratory and sleep homeostasis during upper airway obstruction in rats.Orexin OX2 Receptor Antagonists as Sleep Aids.Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.Distinct effects of IPSU and suvorexant on mouse sleep architecture.Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology.Orexin and Central Modulation of Cardiovascular and Respiratory Function.Practitioner Review: Treatment of chronic insomnia in children and adolescents with neurodevelopmental disabilities.
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P2860
Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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name
Dual hypocretin receptor antag ...... onism of either receptor alone
@ast
Dual hypocretin receptor antag ...... onism of either receptor alone
@en
Dual hypocretin receptor antag ...... onism of either receptor alone
@nl
type
label
Dual hypocretin receptor antag ...... onism of either receptor alone
@ast
Dual hypocretin receptor antag ...... onism of either receptor alone
@en
Dual hypocretin receptor antag ...... onism of either receptor alone
@nl
prefLabel
Dual hypocretin receptor antag ...... onism of either receptor alone
@ast
Dual hypocretin receptor antag ...... onism of either receptor alone
@en
Dual hypocretin receptor antag ...... onism of either receptor alone
@nl
P2093
P2860
P3181
P1433
P1476
Dual hypocretin receptor antag ...... onism of either receptor alone
@en
P2093
Daniel Valladao
Edilio Borroni
Florent G Revel
Jean-Luc Moreau
Joseph G Wettstein
Pari Malherbe
Stephen R Morairty
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0039131
P407
P577
2012-01-01T00:00:00Z