Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

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http://www.wikidata.org/entity/Q27301252
Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patientsEffect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates.Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington DiseaseStudying polyglutamine diseases in Drosophila.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.Regulatory mechanisms of incomplete huntingtin mRNA splicing
P2860

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

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http://www.wikidata.org/entity/Q27301252
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2014 nî lūn-bûn
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2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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Comparative study of naturally ...... pecies in Huntington's disease
@ast
Comparative study of naturally ...... pecies in Huntington's disease
@en
Comparative study of naturally ...... pecies in Huntington's disease
@nl
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label
Comparative study of naturally ...... pecies in Huntington's disease
@ast
Comparative study of naturally ...... pecies in Huntington's disease
@en
Comparative study of naturally ...... pecies in Huntington's disease
@nl
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Comparative study of naturally ...... pecies in Huntington's disease
@ast
Comparative study of naturally ...... pecies in Huntington's disease
@en
Comparative study of naturally ...... pecies in Huntington's disease
@nl
P1433
P1476
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P932
P3181
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P1433
P1476
Comparative study of naturally ...... pecies in Huntington's disease
@en
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P932