Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila - Wikidata - wikimedia - TriplyDB

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

http://www.wikidata.org/entity/Q29616737

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Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1 Huntingtin interacting proteins are genetic modifiers of neurodegeneration Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in Drosophila The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors Life extension in Drosophila by feeding a drug.Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease Huntingtin in health and disease Multiple Aspects of Gene Dysregulation in Huntington's Disease Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.Connecting the dots in Huntington's disease with protein interaction networks Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Nucleolar dysfunction in Huntington's disease The emerging role of acetylation in the regulation of autophagy Huntington's disease: the past, present, and future search for disease modifiers.Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy The interplay between microRNAs and histone deacetylases in neurological diseases Huntington's disease: underlying molecular mechanisms and emerging concepts Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling Pulsed Light Stimulation Increases Boundary Preference and Periodicity of Episodic Motor Activity in Drosophila melanogaster High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model Huntingtin's function in axonal transport is conserved in Drosophila melanogaster A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration The promise and perils of HDAC inhibitors in neurodegeneration Drosophila as an In Vivo Model for Human Neurodegenerative Disease

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P2860

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

http://www.wikidata.org/entity/Q29616737

description

2001 nî lūn-bûn

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2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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type

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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Histone deacetylase inhibitors ...... eurodegeneration in Drosophila

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A Kazantsev

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A McCampbell

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B L Apostol

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J Pallos

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J S Steffan

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L M Thompson

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10.1038/35099568

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1025528785

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11607033

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